Pseudoexfoliation as a risk factor for peripheral vascular disease: A case-control study

Praveen, M. R., Shah, S. K., Vasavada, A. R., Diwan, R. P., Shah, S. M., Zumkhawala, B. R. and Thomas, R. (2011) Pseudoexfoliation as a risk factor for peripheral vascular disease: A case-control study. Eye, 25 2: 174-179. doi:10.1038/eye.2010.175

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Author Praveen, M. R.
Shah, S. K.
Vasavada, A. R.
Diwan, R. P.
Shah, S. M.
Zumkhawala, B. R.
Thomas, R.
Title Pseudoexfoliation as a risk factor for peripheral vascular disease: A case-control study
Journal name Eye   Check publisher's open access policy
ISSN 0950-222X
Publication date 2011-02
Year available 2010
Sub-type Article (original research)
DOI 10.1038/eye.2010.175
Volume 25
Issue 2
Start page 174
End page 179
Total pages 6
Editor A. J. Lotery
Place of publication London, U.K.
Publisher Nature Publishing Group
Collection year 2011
Language eng
Formatted abstract
Aim  To determine the association between pseudoexfoliation (PEX) and peripheral vascular disease (PVD) among age-related cataract.

Setting  Iladevi Cataract and IOL Research Center, Ahmedabad, India.

Material and methods  An observational age-matched case-control study of 160 patients over 60 years of age with age-related cataract. A total of 40 subjects with PEX (cases) were compared with 120 subjects with cataract but without PEX (controls). A detailed medical history, including hypertension, diabetes mellitus, cerebrovascular stroke and ischaemic heart disease, was recorded. Ankle brachial index (ABI) was used to determine the risk of PVD among age-related cataract patients. Color Doppler imaging was performed on the brachial and dorsalis pedis artery to measure ABI and detect PVD. Least mean ABI was the main outcome measure, as low ABI indicates higher risk for PVD. The lowest mean ABI was measured for each subject. An ABI ratio of <0.90 was considered abnormal. The Mann–Whitney U-test and logistic regression were used for analysis.

Results  The lowest mean ABI in the controls was 0.98±0.03 (SD; a range of 0.86–1.08) as compared with 0.88±0.02 (SD) among the cases (a range of 0.79–0.92; P<0.001). When compared with controls, cases had a lower ABI (P<0.001) irrespective of the presence or absence of systemic illness. On multiple regression analysis adjusting for systemic illness, the presence of PEX increased the odds of a low ABI group 150 times (P<0.001).

Conclusion  Subjects with cataract and PEX had a significantly lower ABI as compared with controls (cataracts without PEX). PEX is associated with and may be a risk factor for PVD.
© 2011 Macmillan Publishers Limited All rights reserved
Keyword Pseudoexfoliation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 3 December 2010. Presented in part as a paper at American Academy of Ophthalmology, 11–14 November 2006; Las Vegas, NV, USA.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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