Molecular architecture of the human specialised atrioventricular conduction axis

Greener, I. D., Monfredi, O., Inada, S., Chandler, N. J, Tellez, J.O., Atkinson, A., Taube, M. A., Billeter, R., Anderson, R. H., Efimov, I. R., Molenaar, P., Sigg, D. C., Sharma, V., Boyett, M. R. and Dobrzynski, H. (2011) Molecular architecture of the human specialised atrioventricular conduction axis. Journal of Molecular and Cellular Cardiology, 50 4: 642-651. doi:10.1016/j.yjmcc.2010.12.017


Author Greener, I. D.
Monfredi, O.
Inada, S.
Chandler, N. J
Tellez, J.O.
Atkinson, A.
Taube, M. A.
Billeter, R.
Anderson, R. H.
Efimov, I. R.
Molenaar, P.
Sigg, D. C.
Sharma, V.
Boyett, M. R.
Dobrzynski, H.
Title Molecular architecture of the human specialised atrioventricular conduction axis
Journal name Journal of Molecular and Cellular Cardiology   Check publisher's open access policy
ISSN 0022-2828
Publication date 2011-04
Sub-type Article (original research)
DOI 10.1016/j.yjmcc.2010.12.017
Volume 50
Issue 4
Start page 642
End page 651
Total pages 10
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2012
Language eng
Abstract The atrioventricular conduction axis, located in the septal component of the atrioventricular junctions, is arguably the most complex structure in the heart. It fulfils a multitude of functions, including the introduction of a delay between atrial and ventricular systole and backup pacemaking. Like any other multifunctional tissue, complexity is a key feature of this specialised tissue in the heart, and this complexity is both anatomical and electrophysiological, with the two being inextricably linked. We used quantitative PCR, histology and immunohistochemistry to analyse the axis from six human subjects. mRNAs for ~50 ion and gap junction channels, Ca2+-handling proteins and markers were measured in the atrial muscle (AM), a transitional area (TA), inferior nodal extension (INE), compact node (CN), penetrating bundle (PB) and ventricular muscle (VM). When compared to the AM, we found a lower expression of Nav1.5, Kir2.1, Cx43 and ANP mRNAs in the CN for example, but a higher expression of HCN1, HCN4, Cav1.3, Cav3.1, Kir3.4, Cx40 and Tbx3 mRNAs. Expression of some related proteins was in agreement with the expression of the corresponding mRNAs. There is a complex and heterogeneous pattern of expression of ion and gap junction channels and Ca2+- handling proteins in the human atrioventricular conduction axis that explains the function of this crucial pathway.
Keyword Atrioventricular node
Ion channels
Gap junctions
Arrhythmias
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 36 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 27 Mar 2011, 00:06:21 EST