Oxygen concentration regulates expression and uptake of transthyretin, a thyroxine binding protein, in JEG-3 choriocarcinoma cells

Patel, J., Landers, K., Li, H., Mortimer, R.H. and Richard, K. (2011) Oxygen concentration regulates expression and uptake of transthyretin, a thyroxine binding protein, in JEG-3 choriocarcinoma cells. Placenta, 32 2: 128-133. doi:10.1016/j.placenta.2010.11.016


Author Patel, J.
Landers, K.
Li, H.
Mortimer, R.H.
Richard, K.
Title Oxygen concentration regulates expression and uptake of transthyretin, a thyroxine binding protein, in JEG-3 choriocarcinoma cells
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
Publication date 2011-02
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.placenta.2010.11.016
Volume 32
Issue 2
Start page 128
End page 133
Total pages 6
Place of publication United Kingdom
Publisher Elsevier Ltd
Collection year 2011
Language eng
Formatted abstract
Maternal thyroid hormone is provided to the fetus before the onset of fetal thyroid function (at about 16 weeks) and is essential for normal neurologic development. Mechanisms of transport are uncertain but transthyretin (TTR), a thyroxine binding protein produced by the placenta may be involved. Placental oxygen concentrations in early pregnancy are low, about 1% early in the first trimester and rising to 8% over the next 12 weeks. This study investigated the regulation of TTR expression, secretion and uptake in JEG-3 placental cells cultured at different oxygen concentrations. TTR mRNA and protein expression and 125I-TTR and Alexa-Fluor594-TTR uptake were significantly higher in cells cultured at 1% and 3% O2, than at 8% O2. This suggests that increased carrier mediated T4 transport by placental TTR may be induced by the low oxygen environment of early pregnancy, a time when the fetus has its highest requirement for transport of maternal T4. © 2010 Elsevier Ltd. All rights reserved.
Keyword Transthyretin (TTR)
Thyroxine (T-4)
Placenta
Hypoxia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 27 Mar 2011, 00:02:46 EST