Multilayered nanomedicine delivery system and method

Leary, J. F. and Prow, T. W. (2005). Multilayered nanomedicine delivery system and method. International App. Num.: PCT/US2005/006692.

Creator Leary, J. F.
Prow, T. W.
Patent title Multilayered nanomedicine delivery system and method
Date of issue 2005-09-15
Patent number International App. Num.: PCT/US2005/006692
Country of origin USA
Subjects 100709 Nanomedicine
Abstract/Summary The disclosure provides a nanodelivery system and related process having complex, multilayered nanoparticles for sophisticated drug/gene delivery systems to intracellular portions of a cell. Outermost layers can include cell targeting and cell-entry facilitating molecules. The next layer can include intracellular targeting molecules for precise delivery of the nanoparticle complex inside the cell off interest. Molecular biosensors can be used to confirm the presence of expected molecules as a surrogate molecule for signs of infection, for activation in radiation damage, or other criteria, prior to delivery of counter-measure molecules such as drugs or gene therapy. The biosensors can also be used as a feedback control mechanism to control the proper amount of drug/gene delivery for each cell. Further, the nanodelivery system can be used to restrict any cells from encountering the drug unless that cell is specifically targeted. Successful targeting can be verified by 3D multispectral confocal microscopy.

Document type: Patent
Collection: School of Medicine Publications
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Created: Tue, 22 Mar 2011, 16:10:35 EST by Dr Tarl Prow on behalf of Medicine - Princess Alexandra Hospital