Bacterial cytotoxicity and induction of apoptosis in promyelocytic (line HL-60) cells by novel organotellurium compounds

Sailer, Brian L., Prow, Tarl, Dickerson, Sarah, Watson, John, Liles, Nathan, Patel, Shiv J., Van Fleet-Stalder, Verena and Chasteen, Thomas G. (1999) Bacterial cytotoxicity and induction of apoptosis in promyelocytic (line HL-60) cells by novel organotellurium compounds. Environmental Toxicology and Chemistry, 18 12: 2926-2933. doi:10.1897/1551-5028(1999)018<2926:BCAIOA>2.3.CO;2


Author Sailer, Brian L.
Prow, Tarl
Dickerson, Sarah
Watson, John
Liles, Nathan
Patel, Shiv J.
Van Fleet-Stalder, Verena
Chasteen, Thomas G.
Title Bacterial cytotoxicity and induction of apoptosis in promyelocytic (line HL-60) cells by novel organotellurium compounds
Journal name Environmental Toxicology and Chemistry   Check publisher's open access policy
ISSN 0730-7268
1552-8618
Publication date 1999-12
Sub-type Article (original research)
DOI 10.1897/1551-5028(1999)018<2926:BCAIOA>2.3.CO;2
Volume 18
Issue 12
Start page 2926
End page 2933
Total pages 8
Place of publication Pensacola, FL, U.S.A.
Publisher Society of Environmental Toxicology and Chemistry
Language eng
Formatted abstract
The increasing importance of tellurium in organic synthesis, in industrial applications, and as a possible component in pesticides means that its introduction into the environment will probably increase in the future. A knowledge of the relative toxicity and the mode of toxic action of tellurium-containing chemicals is therefore important. The work presented here, using growth-rate inhibition effects on Pseudomonas fluorescens of two model compounds, telluranthrene and tetrachlorodiphenyl ditelluride, suggests that these compounds are at least as toxic as the relatively well-known selenium oxyanions, selenate and selenite. Experiments with human promyelocytic (line HL-60) cells indicate that both the above organotellurium compounds induce a form of cell death called apoptosis, or programmed cell death. The induction of apoptosis occurred in both a time- and dose-dependent manner, as assayed by three different analytical methods: fluorescence microscopy, flow cytometry, and gel electrophoresis. The results indicate that organotellurium compounds may find applicability in the fields of chemoprevention and cancer therapy, similar to organoselenium compounds.
© 1999 SETAC
Keyword Organotellurium
Telluranthrene
Tetrachlorodiphenyl ditelluride
Apoptosis
Cytotoxicity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 21 Mar 2011, 15:20:36 EST by Dr Tarl Prow on behalf of Medicine - Princess Alexandra Hospital