Expression and in vitro functions of the ghrelin axis in endometrial cancer

Fung, Jenny N. T., Seim, Inge, Wang, Dengfeng, Obermair, Andreas, Chopin, Lisa K. and Chen, Chen (2010) Expression and in vitro functions of the ghrelin axis in endometrial cancer. Hormone and Cancer, 1 5: 245-255. doi:10.1007/s12672-010-0047-1

Author Fung, Jenny N. T.
Seim, Inge
Wang, Dengfeng
Obermair, Andreas
Chopin, Lisa K.
Chen, Chen
Title Expression and in vitro functions of the ghrelin axis in endometrial cancer
Journal name Hormone and Cancer   Check publisher's open access policy
ISSN 1868-8497
Publication date 2010-10
Sub-type Article (original research)
DOI 10.1007/s12672-010-0047-1
Volume 1
Issue 5
Start page 245
End page 255
Total pages 11
Place of publication New York, NY, U.S.A.
Publisher Springer New York LLC
Collection year 2011
Language eng
Formatted abstract
Ghrelin is a peptide hormone produced in the stomach and a range of other tissues, where it has endocrine, paracrine and autocrine roles in both normal and disease states. Ghrelin has been shown to be an important growth factor for a number of tumours, including prostate and breast cancers. In this study, we examined the expression of the ghrelin axis (ghrelin and its receptor, the growth hormone secretagogue receptor, GHSR) in endometrial cancer. Ghrelin is expressed in a range of endometrial cancer tissues, while its cognate receptor, GHSR1a, is expressed in a small subset of normal and cancer tissues. Low to moderately invasive endometrial cancer cell lines were examined by RT–PCR and immunoblotting, demonstrating that ghrelin axis mRNA and protein expression correlate with differentiation status of Ishikawa, HEC1B and KLE endometrial cancer cell lines. Moreover, treatment with ghrelin potently stimulated cell proliferation and inhibited cell death. Taken together, these data indicate that ghrelin promotes the progression of endometrial cancer cells in vitro, and may contribute to endometrial cancer pathogenesis and represent a novel treatment target.
© Springer
Keyword Ghrelin
Growth hormone secretagogue receptor
Endometrial cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
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Created: Mon, 21 Mar 2011, 15:02:33 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences