Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions

Windus, Louisa C. E., Lineburg, Katie E., Scott, Susan E., Claxton, Christina, Mackay-Sim, Alan, Key, Brian and St John, James A. (2010) Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions. Cellular and Molecular Life Sciences, 67 10: 1735-1750. doi:10.1007/s00018-010-0280-3

Author Windus, Louisa C. E.
Lineburg, Katie E.
Scott, Susan E.
Claxton, Christina
Mackay-Sim, Alan
Key, Brian
St John, James A.
Title Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-682X
Publication date 2010-05
Sub-type Article (original research)
DOI 10.1007/s00018-010-0280-3
Volume 67
Issue 10
Start page 1735
End page 1750
Total pages 16
Editor Klaus Eichmann
Place of publication Basel, Switzerland
Publisher Birkhaeuser Verlag
Collection year 2011
Language eng
Formatted abstract
The growth and guidance of primary olfactory axons are partly attributed to the presence of olfactory ensheathing cells (OECs). However, little is understood about the differences between the subpopulations of OECs and what regulates their interactions. We used OEC-axon assays and determined that axons respond differently to peripheral and central OECs. We then further purified OECs from anatomically distinct regions of the olfactory bulb. Cell behaviour assays revealed that OECs from the olfactory bulb were a functionally heterogeneous population with distinct differences which is consistent with their proposed roles in vivo. We found that the heterogeneity was regulated by motile lamellipodial waves along the shaft of the OECs and that inhibition of lamellipodial wave activity via Mek1 abolished the ability of the cells to distinguish between each other. These results demonstrate that OECs from the olfactory bulb are a heterogeneous population that use lamellipodial waves to regulate cell–cell recognition.
© Springer Basel AG 2010
Keyword Olfactory bulb
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 39 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 21 Mar 2011, 13:35:23 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences