Improvement of the wet tensile properties of nanostructured hydroxyapatite and chitosan biocomposite films through hydrophobic modification

Pradal, Clementine, Kithva, Prakash, Martin, Darren, Trau, Matt and Grøndahl, Lisbeth (2011) Improvement of the wet tensile properties of nanostructured hydroxyapatite and chitosan biocomposite films through hydrophobic modification. Journal of Materials Chemistry, 21 7: 2330-2337. doi:10.1039/c0jm03080e


Author Pradal, Clementine
Kithva, Prakash
Martin, Darren
Trau, Matt
Grøndahl, Lisbeth
Title Improvement of the wet tensile properties of nanostructured hydroxyapatite and chitosan biocomposite films through hydrophobic modification
Journal name Journal of Materials Chemistry   Check publisher's open access policy
ISSN 0959-9428
1364-5501
Publication date 2011-02-21
Year available 2010
Sub-type Article (original research)
DOI 10.1039/c0jm03080e
Open Access Status Not Open Access
Volume 21
Issue 7
Start page 2330
End page 2337
Total pages 8
Editor Liz Davies
Place of publication Cambridge, U.K .
Publisher Royal Society of Chemistry
Collection year 2011
Language eng
Formatted abstract
Hydrophobic modification of chitosan/hydroxyapatite composites and chitosan films was performed using four n-alkyl acids with varying alkyl chain lengths (6 to 16 carbons), and these films were characterized for their hydrophobicity and tensile properties under wet conditions. Grafting was performed by a heterogeneous reaction in a 2.0 mol L−1 DMF solution of the acid at 80 °C for either one or five days. Characterisation by Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS) verified the introduction of amide functionalities and alkyl chains. The degree of substitution (DS) ranged from 2–5% for the composite films (based on XPS N 1s narrow scans) reflecting the heterogeneous nature of the reaction. Water contact angle measurements and the tensile testing under wet conditions showed, in general, that the grafting time and alkyl chain length had little effect on the surface hydrophobicity and the tensile properties of films, respectively. However, these modifications had a pronounced effect on decreasing the water content of the films, suggesting that the grafting had occurred in the bulk of the film for longer grafting times. In contrast, the tensile properties of the grafted composite films were significantly improved relative to non-grafted films and a modulus of 393 ± 68 MPa and an UTS of 18.7 ± 1.5 MPa were reached for composite films grafted for one day. This study provides a simple method to improve the wet tensile properties of chitosan/hydroxyapatite composite films making them more suitable for biomedical applications.
© The Royal Society of Chemistry 2011
Keyword Chitosan/hydroxyapatite nanocomposites
Physical-properties
In-vitro
Bone
Chitin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 20 Mar 2011, 00:09:04 EST