Cognitive function in adolescence: Testing for interactions between breast-feeding and FADS2 polymorphisms

Martin, Nicolas W., Benyamin, Beben, Hansell, Narelle K., Montgomery, Grant W., Martin, Nicholas G., Wright, Margaret J. and Bates, Timothy C. (2011) Cognitive function in adolescence: Testing for interactions between breast-feeding and FADS2 polymorphisms. Journal of the American Academy of Child and Adolescent Psychiatry, 50 1: 55-62.e4. doi:10.1016/j.jaac.2010.10.010

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Author Martin, Nicolas W.
Benyamin, Beben
Hansell, Narelle K.
Montgomery, Grant W.
Martin, Nicholas G.
Wright, Margaret J.
Bates, Timothy C.
Title Cognitive function in adolescence: Testing for interactions between breast-feeding and FADS2 polymorphisms
Formatted title
Cognitive function in adolescence: Testing for interactions between breast-feeding and FADS2 polymorphisms
Journal name Journal of the American Academy of Child and Adolescent Psychiatry   Check publisher's open access policy
ISSN 0890-8567
1527-5418
Publication date 2011-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.jaac.2010.10.010
Volume 50
Issue 1
Start page 55
End page 62.e4
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2011
Language eng
Formatted abstract
Objectives Breast-fed C-allele carriers of the rs174575 single nucleotide polymorphism in the fatty acyl desaturase 2 (FADS2) gene have been reported to show a 6.4 to 7 IQ point advantage over formula-fed C-allele carriers, with no effect of breast-feeding in GG carriers. An Australian sample was examined to determine if an interaction between breast-feeding and the rs174575 single nucleotide polymorphism had any effect on IQ.
Method This hypothesis was tested in more than 700 families of adolescent twins assessed for IQ and breast-feeding, birth weight, and FADS2 polymorphisms, and parental socioeconomic status and education, and maternal FADS2 status.
Results No significant evidence for a moderating effect on IQ of rs174575 C-carrier status and breast-feeding was found, and there no effects of maternal FADS2 status on offspring IQ. In addition, no main effects of any FADS2 polymorphisms on IQ were found when the genotype was kept as two-homozygote and one-heterozygote categories and indeed no evidence for effects of breast-feeding on IQ scores after controlling for parental socioeconomic status and education. The investigation was extended to two additional FADS2 polymorphisms (rs1535 and rs174583), but again, although these polymorphisms code alleles affecting fatty acid metabolism, no main or interaction effects were found on IQ.
Conclusion These results support the view that apparent effects of breast-feeding on IQ reflect differential likelihood of breast-feeding as a function of parental education and did not support the predicted interaction effect of FADS2 and breast-feeding on IQ.
© 2011 American Academy of Child and Adolescent Psychiatry.
Keyword Breast-feeding
IQ gene-environment interactions
fatty acid metabolism
FADS2
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 3 December 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
School of Psychology Publications
 
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Created: Sun, 20 Mar 2011, 00:07:55 EST