Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki

Sebe-Pedros, Arnau, de Mendoza, Alex, Lang, B. Franz, Degnan, Bernard M. and Ruiz-Trillo, Inaki (2011) Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki. Molecular Biology and Evolution, 28 3: 1241-1254. doi:10.1093/molbev/msq309


Author Sebe-Pedros, Arnau
de Mendoza, Alex
Lang, B. Franz
Degnan, Bernard M.
Ruiz-Trillo, Inaki
Title Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki
Formatted title
Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki
Journal name Molecular Biology and Evolution   Check publisher's open access policy
ISSN 0737-4038
1537-1719
Publication date 2011-03
Year available 2010
Sub-type Article (original research)
DOI 10.1093/molbev/msq309
Volume 28
Issue 3
Start page 1241
End page 1254
Total pages 14
Place of publication Cary, NC, United States
Publisher Oxford University Press
Collection year 2011
Language eng
Formatted abstract
How animals (metazoans) originated from their single-celled ancestors remains a major question in biology. As transcriptional regulation is crucial to animal development, deciphering the early evolution of associated transcription factors (TFs) is critical to understanding metazoan origins. In this study, we uncovered the repertoire of 17 metazoan TFs in the amoeboid holozoan Capsaspora owczarzaki, a representative of a unicellular lineage that is closely related to choanoflagellates and metazoans. Phylogenetic and comparative genomic analyses with the broadest possible taxonomic sampling allowed us to formulate new hypotheses regarding the origin and evolution of developmental metazoan TFs. We show that the complexity of the TF repertoire in C. owczarzaki is strikingly high, pushing back further the origin of some TFs formerly thought to be metazoan specific, such as T-box or Runx. Nonetheless, TF families whose beginnings antedate the origin of the animal kingdom, such as homeodomain or basic helix-loop-helix, underwent significant expansion and diversification along metazoan and eumetazoan stems. © The Author 2010. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.
Keyword Multicellularity
T-box
Homeodomain
Brachyury
Origin Metazoa
Choanoflagellates
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online: November 17, 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biological Sciences Publications
 
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Created: Sun, 20 Mar 2011, 00:05:43 EST