Skin abrasion: Transdermal delivery, cosmetic and immunological applications

Grice, J. E. and Roberts, M. S. (2010) Skin abrasion: Transdermal delivery, cosmetic and immunological applications. Transdermal, 2 1: 11-16.

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Author Grice, J. E.
Roberts, M. S.
Title Skin abrasion: Transdermal delivery, cosmetic and immunological applications
Journal name Transdermal
ISSN 1948-3600
1948-5824
Publication date 2010-01
Sub-type Critical review of research, literature review, critical commentary
Volume 2
Issue 1
Start page 11
End page 16
Total pages 6
Editor P. Wright
Place of publication Saint Paul, MN, U.S.A.
Publisher CSC Publishing
Collection year 2011
Language eng
Formatted abstract
Cosmetic skin abrasion, generally performed as microdermabrasion where a stream of crystalline material is directed at the skin, is a safe and minimally invasive procedure. To understand the use of skin abrasion for transdermal drug delivery, including vaccine delivery and immunotherapy, it helps to understand the history of its use cosmetically and to review research on use of the technique for cosmetic applications. Although doctors perceive skin abrasion as a valuable tool for improving the texture and appearance of scarred or damaged skin, scientists incompletely understand the mechanisms by which the technique achieves the skin enhancement. They believe the process may involve stratum corneum remodeling and initiation of a dermal remodeling and wound healing cascade. In-vitro investigations show that skin abrasion can enhance transdermal permeation of materials that normally penetrate skin very poorly or not at all, but once again, scientists do not understand the mechanism fully. Researchers are investigating the mechanism, and commercial applications for therapeutic delivery and vaccination are likely.

This article provides a brief overview of the cosmetic, transdermal drug delivery, and immunological applications of skin abrasion.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Sat, 19 Mar 2011, 10:43:26 EST by Dr Jeffrey Grice on behalf of School of Medicine