Transferrin receptor 1: A ferritin receptor as well?

Wallace, Daniel F., McDonald, Cameron and Subramaniam, V. Nathan (2010) Transferrin receptor 1: A ferritin receptor as well?. Gastroenterology, 139 3: 1052-1053. doi:10.1053/j.gastro.2010.07.030

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Author Wallace, Daniel F.
McDonald, Cameron
Subramaniam, V. Nathan
Title Transferrin receptor 1: A ferritin receptor as well?
Journal name Gastroenterology   Check publisher's open access policy
ISSN 0016-5085
Publication date 2010-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1053/j.gastro.2010.07.030
Volume 139
Issue 3
Start page 1052
End page 1053
Total pages 2
Editor Anil A. Rustgi
Gary R. Lichtenstein
Place of publication Maryland Heights, MO, U.S.A.
Publisher W.B. Saunders
Collection year 2011
Language eng
Formatted abstract
This study by Li et al (Proc Natl Acad Sci U S A 2010;107:3505–3510) used expression cloning to identify receptors for HFt in human cells. They identified the ubiquitous TfR1 as a receptor for HFt, which is capable of internalizing the ligand and responsible for its uptake into endosomes and lysosomes. The authors go on to demonstrate that this interaction is partially inhibited by diferric-Tf (Fe-Tf), but independent of HFE, and that TfR1 accounts for most of the HFt binding in all the cells studied.

In conclusion, this paper has provided novel insights into 2 of the most recognized and well-studied players in iron biology, highlighting the fact that there is more to learn about even the most well-established proteins.
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under "Selected Summaries". Subtitle: "Li L, Fang CJ, Ryan JC, et al. (Department of Medicine, Veterans Administration Medical Center, San Francisco, CA; others). Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A 2010;107:3505–3510."

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
School of Medicine Publications
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Created: Fri, 18 Mar 2011, 11:49:10 EST by Therese Murphy on behalf of Medicine - Princess Alexandra Hospital