Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies

Reichert, Johannes C., Epari, Devakara R., Wullschleger, Martin E., Saifzadeh, Siamak, Steck, Roland, Lienau, Jasmin, Sommerville, Scott, Dickinson, Ian C., Schutz, Michael A., Duda, Georg N. and Hutmacher, Dietmar W. (2010) Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies. Tissue Engineering - Part B: Reviews, 16 1: 93-104. doi:10.1089/ten.teb.2009.0455

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Author Reichert, Johannes C.
Epari, Devakara R.
Wullschleger, Martin E.
Saifzadeh, Siamak
Steck, Roland
Lienau, Jasmin
Sommerville, Scott
Dickinson, Ian C.
Schutz, Michael A.
Duda, Georg N.
Hutmacher, Dietmar W.
Title Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies
Journal name Tissue Engineering - Part B: Reviews   Check publisher's open access policy
ISSN 1937-3368
Publication date 2010-02
Sub-type Article (original research)
DOI 10.1089/ten.teb.2009.0455
Volume 16
Issue 1
Start page 93
End page 104
Total pages 12
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert Publishers
Collection year 2011
Language eng
Abstract Currently, well-established clinical therapeutic approaches for bone reconstruction are restricted to the transplantation of autografts and allografts, and the implantation of metal devices or ceramic-based implants to assist bone regeneration. Bone grafts possess osteoconductive and osteoinductive properties; however, they are limited in access and availability and associated with donor-site morbidity, hemorrhage, risk of infection, insufficient transplant integration, graft devitalization, and subsequent resorption resulting in decreased mechanical stability. As a result, recent research focuses on the development of alternative therapeutic concepts. The field of tissue engineering has emerged as an important approach to bone regeneration. However, bench-to-bedside translations are still infrequent as the process toward approval by regulatory bodies is protracted and costly, requiring both comprehensive in vitro and in vivo studies. The subsequent gap between research and clinical translation, hence, commercialization, is referred to as the "Valley of Death" and describes a large number of projects and/or ventures that are ceased due to a lack of funding during the transition from product/technology development to regulatory approval and subsequently commercialization. One of the greatest difficulties in bridging the Valley of Death is to develop good manufacturing processes and scalable designs and to apply these in preclinical studies. In this article, we describe part of the rationale and road map of how our multidisciplinary research team has approached the first steps to translate orthopedic bone engineering from bench to bedside by establishing a preclinical ovine critical-sized tibial segmental bone defect model, and we discuss our preliminary data relating to this decisive step.
Keyword Animals
Disease models, animal
External fixators
Finite element analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 18 Mar 2011, 11:29:45 EST by Mrs Maureen Pollard on behalf of PA - Southside Clinical School