A genome-wide association study of self-rated health

Mosing, Miriam A., Verweij, Karin J. H., Medland, Sarah E., Painter, Jodie, Gordon, Scott D., Heath, Andrew C., Madden, Pamela A., Montgomery, Grant W. and Martin, Nicholas G. (2010) A genome-wide association study of self-rated health. Twin Research and Human Genetics, 13 4: 398-403. doi:10.1375/twin.13.4.398

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Author Mosing, Miriam A.
Verweij, Karin J. H.
Medland, Sarah E.
Painter, Jodie
Gordon, Scott D.
Heath, Andrew C.
Madden, Pamela A.
Montgomery, Grant W.
Martin, Nicholas G.
Title A genome-wide association study of self-rated health
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
Publication date 2010-08
Year available 2010
Sub-type Article (original research)
DOI 10.1375/twin.13.4.398
Volume 13
Issue 4
Start page 398
End page 403
Total pages 6
Editor Nicholas G. Martin
Place of publication Bowen Hills, QLD, Australia
Publisher Australian Academic Press
Collection year 2011
Language eng
Abstract Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25–64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18–92. No genome wide significant SNPs associated with self-rated health could be identified, indicating that self-rated health may be influenced by a large number of SNPs with very small effect size. A very large sample will be needed to identify these SNPs.
Keyword Genome-wide association
Genes
Self-rated health
Self-reported health
Health
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Psychology Publications
 
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Created: Wed, 16 Mar 2011, 10:18:08 EST by Lucy O'Brien on behalf of School of Psychology