Immunology of multiple sclerosis

Pender, Michael P. and Greer, Judith M. (2007) Immunology of multiple sclerosis. Current Allergy and Asthma Reports, 7 4: 285-292. doi:10.1007/s11882-007-0043-x

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Author Pender, Michael P.
Greer, Judith M.
Title Immunology of multiple sclerosis
Journal name Current Allergy and Asthma Reports   Check publisher's open access policy
ISSN 1529-7322
Publication date 2007-07-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11882-007-0043-x
Open Access Status File (Author Post-print)
Volume 7
Issue 4
Start page 285
End page 292
Total pages 8
Editor Kaliner, Michael A.
Place of publication Philadelphia, PA, U.S.A
Publisher Current Medicine Group
Collection year 2008
Language eng
Subject 320207 Autoimmunity
321013 Neurology and Neuromuscular Diseases
320200 Immunology
730104 Nervous system and disorders
Abstract Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) leading to demyelination, axonal damage, and progressive neurologic disability. The development of MS is influenced by environmental factors, particularly the Epstein-Barr virus (EBV), and genetic factors, which include specific HLA types, particularly DRB1*1501-DQA1*0102-DQB1*0602, and a predisposition to autoimmunity in general. MS patients have increased circulating T-cell and antibody reactivity to myelin proteins and gangliosides. It is proposed that the role of EBV is to infect autoreactive B cells that then seed the CNS and promote the survival of autoreactive T cells there. It is also proposed that the clinical attacks of relapsing-remitting MS are orchestrated by myelin-reactive T cells entering the white matter of the CNS from the blood, and that the progressive disability in primary and secondary progressive MS is caused by the action of autoantibodies produced in the CNS by ­meningeal lymphoid follicles with germinal centers.
Keyword Autoimmunity
B cell
Cerebral cortex
Epstein-Barr virus
Germinal centre
Primary progressive multiple sclerosis
Secondary progressive multiple sclerosis
Meningeal lymphoid follicle
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Author supplied copy. Copyright © 2007 by Current Medicine Group

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 44 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 08 Jun 2007, 14:10:14 EST by Belinda Weaver on behalf of School of Medicine