Is there a place on the shelf for Aliskiren?

Pimenta, Eduardo (2010) Is there a place on the shelf for Aliskiren?. Current Cardiovascular Risk Reports, 4 4: 264-270. doi:10.1007/s12170-010-0108-6

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Author Pimenta, Eduardo
Title Is there a place on the shelf for Aliskiren?
Journal name Current Cardiovascular Risk Reports   Check publisher's open access policy
ISSN 1932-9563
Publication date 2010-07
Sub-type Article (original research)
DOI 10.1007/s12170-010-0108-6
Volume 4
Issue 4
Start page 264
End page 270
Total pages 7
Place of publication Philadelphia, PA, U.S.A.
Publisher Current Medicine Group
Collection year 2011
Language eng
Formatted abstract
Increased renin-angiotensin-aldosterone system (RAAS) activity contributes to target-organ damage and increases cardiovascular risk by elevating blood pressure (BP) and through direct effects on the heart, kidneys, brain, and vascular endothelium. Pharmacologic blockade of RAAS effectively reduces BP and limits or reverses various forms of target-organ damage, including cardiac heart failure, coronary artery disease, chronic kidney disease, and left ventricular hypertrophy. Direct renin inhibitors selectively inhibit human renin and have a therapeutic potential similar to angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. Aliskiren is the only orally active direct renin inhibitor that has been approved for the treatment of hypertension and has been shown to have favorable effects on target-organ damage. It effectively reduces BP and has favorable effects on heart failure and proteinuria in diabetic patients. Additional outcome trials are needed to establish the role of this new class of antihypertensive medication in preventing cardiovascular outcomes.
© 2010 Springer Science+Business Media, LLC.
Keyword Hypertension
Renin inhibitors
Renin-angiotensin-aldosterone system
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Created: Tue, 15 Mar 2011, 13:52:05 EST by Debbie Banks on behalf of School of Medicine