No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples

Sullivan, .Patrick F., Fifield, Wendy J., Kennedy, Martin A., Mulder, Roger T., Sellman, J. Douglas and Joyce, Peter R. (1998) No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples. American Journal of Psychiatry, 155 1: 98-101.

Author Sullivan, .Patrick F.
Fifield, Wendy J.
Kennedy, Martin A.
Mulder, Roger T.
Sellman, J. Douglas
Joyce, Peter R.
Title No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples
Journal name American Journal of Psychiatry   Check publisher's open access policy
ISSN 0002-953X
1535-7228
Publication date 1998-01
Sub-type Article (original research)
Volume 155
Issue 1
Start page 98
End page 101
Total pages 4
Place of publication Arlington, VA, United States
Publisher American Psychiatric Publishing
Language eng
Formatted abstract
Objective:
In 1986 and 1987, Cloninger postulated the existence of the heritable behavioral trait of novelty seeking and its putative underpinnings in the dopaminergic systems of the ventral midbrain. Two widely reported studies found significant associations between novelty seeking and the type 4 dopamine receptor gene (DRD4), although a more recent study did not. The authors' objective was to investigate this association in two New Zealand samples.

Method:
The authors studied two nonoverlapping samples: subjects in a depression treatment trial (N=86) and subjects from 14 pedigrees dense with alcoholism (N=181). DRD4 genotyping was based on a standard protocol.

Results:
Novelty seeking and DRD4 were not statistically associated.

Conclusions:
In these samples, there was no suggestion that the DRD4 polymorphism contributed to individual differences in the behavioral trait of novelty seeking.
Keyword Personality
Polymorphism
Temperament
Population
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 15 Mar 2011, 07:47:11 EST