Decrease in frequency of liquid stool in enterally fed critically ill patients given the multispecies probiotic VSL#3: A pilot trial

Frohmader, Terence J., Chaboyer, Wendy P., Robertson, Iain K. and Gowardman, John (2010) Decrease in frequency of liquid stool in enterally fed critically ill patients given the multispecies probiotic VSL#3: A pilot trial. American Journal of Critical Care, 19 3: e1-e11. doi:10.4037/ajcc2010976


Author Frohmader, Terence J.
Chaboyer, Wendy P.
Robertson, Iain K.
Gowardman, John
Title Decrease in frequency of liquid stool in enterally fed critically ill patients given the multispecies probiotic VSL#3: A pilot trial
Journal name American Journal of Critical Care   Check publisher's open access policy
ISSN 1062-3264
1937-710X
Publication date 2010-05
Sub-type Article (original research)
DOI 10.4037/ajcc2010976
Volume 19
Issue 3
Start page e1
End page e11
Total pages 11
Place of publication Aliso Viejo, CA, U.S.A.
Publisher American Association of Critical Care Nurses
Collection year 2011
Language eng
Formatted abstract
Background:
Diarrhea has adverse consequences for critically ill patients, health care staff, and health care costs.

Objective:
To evaluate the efficacy of the multispecies probiotic VSL#3 in reducing the mean number of episodes of liquid stool in enterally fed critically ill patients.

Methods:
A single-center, double-blind, randomized, placebo-controlled pilot study was done in a 6-bed intensive care unit in a 330-bed public hospital in Australia. A total of 45 adults (20 intervention, 25 control) who required enteral nutrition for more than 72 hours were given VSL#3 or a placebo twice daily. The frequency (mean number of episodes per patient per day) and weight (grams per day) were determined for both liquid stool and liquid and loose (unformed) stool.

Results:

The 2 groups of patients had no demographic or clinical differences. Patients received enteral nutrition for a mean of 8.5 days (SD, 5.4) and were studied for a mean of 11.9 days (SD, 5.6). Compared with the control group, the intervention group had a significant reduction in the frequency of liquid stools (incidence rate ratio, 0.50; 95% confidence interval, 0.27 to 0.93; P = .03). Smaller but still significant differences also occurred between the groups in both the frequency of episodes and the weight of liquid and loose (unformed) stool.

Conclusion:
VSL#3 was effective in reducing the frequency of liquid stool in critically ill patients receiving enteral nutrition. Probiotics possibly can minimize diarrhea in critically ill tube-fed patients, but more controlled clinical trials are needed.
©2010 American Association of Critical-Care Nurses

Keyword Antibiotic-associated diarrhea
Placebo-controlled trial
Elective surgical patients
Prevention
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 22 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 14 Mar 2011, 16:23:05 EST by Sia Athanasas on behalf of Anaesthesiology and Critical Care - RBWH