Time post-lung transplant correlates with increasing peripheral blood T cell granzyme B and proinflammatory cytokines

Hodge, G., Hodge, S., Li-Liew, C., Chambers, D., Hopkins, P., Reynolds, P. N. and Holmes, M. (2010) Time post-lung transplant correlates with increasing peripheral blood T cell granzyme B and proinflammatory cytokines. Clinical and Experimental Immunology, 161 3: 584-590. doi:10.1111/j.1365-2249.2010.04186.x

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Author Hodge, G.
Hodge, S.
Li-Liew, C.
Chambers, D.
Hopkins, P.
Reynolds, P. N.
Holmes, M.
Title Time post-lung transplant correlates with increasing peripheral blood T cell granzyme B and proinflammatory cytokines
Journal name Clinical and Experimental Immunology   Check publisher's open access policy
ISSN 0009-9104
1365-2249
0964-2536
Publication date 2010-09
Sub-type Article (original research)
DOI 10.1111/j.1365-2249.2010.04186.x
Volume 161
Issue 3
Start page 584
End page 590
Total pages 7
Editor Mark Peakman
Place of publication Oxford, U.K
Publisher Wiley-Blackwell Publishing
Collection year 2011
Language eng
Formatted abstract
Immunosuppression therapy following lung transplant fails to prevent chronic rejection/bronchiolitis obliterans syndrome, which we have shown is associated with lack of suppression of peripheral blood T cell granzyme B, interferon (IFN)-γ and tumour necrosis factor (TNF)-α. We hypothesized that these proinflammatory mediators may increase with time post-transplant in otherwise stable patients before clinical signs of declining lung function, and patients experiencing declining lung function would show a further increase in these mediators. Intracellular cytokine profiles and granzyme B were investigated in T cells in whole blood and airways from lung transplant patients using flow cytometry. There was a significant negative correlation between forced expiratory volume in 1 s (FEV1), drug dose and time post-transplant. A significant correlation between increased granzyme B, IFN-γ, interleukin (IL)-2 and TNF-α and time post-transplant was noted in peripheral blood T cells but not lung T cells from stable patients. Patients with similar drug dose but experiencing declining FEV1 showed a further increase in peripheral blood T cell IFN-γ, IL-2 and TNF-α. Time post-lung transplant correlates with increasing peripheral blood T cell granzyme B and proinflammatory cytokines. Declining FEV1 is associated with a further increase in these proinflammatory mediators. Drugs that reduce these inflammatory mediators effectively may reduce the incidence of chronic graft rejection.
© 2010 British Society for Immunology
Keyword IFN-γ
IFN-gamma
Lung transplant
T cell granzyme B
Time post-transplant
TNF-α
TNF-alpha
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 15:45:41 EST by Lisa Hennell on behalf of School of Medicine