Radioimmunoscintigraphy of recurrent, metastatic, or occult colorectal cancer with technetium Tc 99m 88BV59H21-2V67-66 (HumaSPECT (R)-Tc), a totally human monoclonal antibody - Patient management benefit from a phase III multicenter study

Wolff, Bruce G., Bolton, John, Baum, Richard, Chetanneau, Alain, Pecking, Alain, Serafini, Aldo N., Fischman, Alan J., Hoover, Herbert C., Klein, Jerry L., Wynant, Gordon E., Subramanian, Ramaswamy, Goroff, Diana K. and Hanna, Michael G. (1998) Radioimmunoscintigraphy of recurrent, metastatic, or occult colorectal cancer with technetium Tc 99m 88BV59H21-2V67-66 (HumaSPECT (R)-Tc), a totally human monoclonal antibody - Patient management benefit from a phase III multicenter study. Diseases of the Colon and Rectum, 41 8: 953-962. doi:10.1007/BF02237380


Author Wolff, Bruce G.
Bolton, John
Baum, Richard
Chetanneau, Alain
Pecking, Alain
Serafini, Aldo N.
Fischman, Alan J.
Hoover, Herbert C.
Klein, Jerry L.
Wynant, Gordon E.
Subramanian, Ramaswamy
Goroff, Diana K.
Hanna, Michael G.
Title Radioimmunoscintigraphy of recurrent, metastatic, or occult colorectal cancer with technetium Tc 99m 88BV59H21-2V67-66 (HumaSPECT (R)-Tc), a totally human monoclonal antibody - Patient management benefit from a phase III multicenter study
Journal name Diseases of the Colon and Rectum   Check publisher's open access policy
ISSN 0012-3706
1530-0358
Publication date 1998-08
Sub-type Article (original research)
DOI 10.1007/BF02237380
Volume 41
Issue 8
Start page 953
End page 962
Total pages 10
Place of publication New York, NY, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
PURPOSE:
T
he study contained herein was undertaken to evaluate the accuracy of radiolabeled human monoclonal antibody, 88BV59H21-2V67-66 (88BV59 or HumaSPECT®-Tc), in predicting disease resectability in presurgical subjects with recurrent, metastatic, or occult colorectal carcinoma.

METHODS:
A total of 219 patients with disease visualized on computed tomographic scan (recurrent or metastatic disease) or with negative or equivocal computed tomographic scan and rising carcinoembryonic antigen serum levels (occult group) received technetium Tc 99m-labeled 88BV59 intravenously. Planar and single photon emission computed tomographic images were obtained 14 to 20 hours postinfusion, before surgery. The ability of computed tomographic and HumaSPECT®-Tc imaging to define the extent of disease and to predict resectability was evaluated based on surgical and histopathologic results.

RESULTS:

In patients with recurrent or metastatic disease (170 evaluable patients), the accuracy of predicting nonresectability of disease was significantly greater (P < 0.001) for HumaSPECT®-Tc than for computed tomography (60 vs. 29 percent). Computed tomography understaged 41 percent of patients believed to have resectable disease compared with 27 percent for HumaSPECT®-Tc (P < 0.001). In occult disease patients (29 computed tomographic and 28 HumaSPECT®-Tc evaluable patients), the overall accuracy of predicting resectability/nonresectability was 68 percent for HumaSPECT®- Tc compared with 24 percent for computed tomography. Administration of HumaSPECT®-Tc had no effect on monoclonal antibody-based in vitro diagnostic assays. Only a single patient demonstrated an anti-antibody response (90 ng/ml) at nine weeks postinfusion.

CONCLUSION:

HumaSPECT®-Tc was more accurate than computed tomography in determining disease resectability in patients with metastatic, recurrent, or occult cancer. The addition of HumaSPECT®-Tc imaging can play a significant role in patient management decisions.
Keyword Human monoclonal antibody
Monoclonal antibody imaging
Technetium
Colorectal cancer
88BV59
HumaSPECT (R)-Tc
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:53:00 EST