Prognostic value of DNA flow cytometry in paragangliomas of the carotid body

Sauter, Edward R., Hollier, Larry H., Bolton, John S., Ochsner, John L. and Sardi, Armando (1991) Prognostic value of DNA flow cytometry in paragangliomas of the carotid body. Journal of Surgical Oncology, 46 3: 151-153. doi:10.1002/jso.2930460304


Author Sauter, Edward R.
Hollier, Larry H.
Bolton, John S.
Ochsner, John L.
Sardi, Armando
Title Prognostic value of DNA flow cytometry in paragangliomas of the carotid body
Journal name Journal of Surgical Oncology   Check publisher's open access policy
ISSN 0022-4790
1096-9098
Publication date 1991-03
Sub-type Article (original research)
DOI 10.1002/jso.2930460304
Volume 46
Issue 3
Start page 151
End page 153
Total pages 3
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract A carotid body tumor is a paraganglioma of the carotid bifurcation. Histologic appearance does not correlate with the malignant potential of the lesion, and thus a reliable prognostic marker for these tumors is lacking. To determine whether flow cytometric analysis of paraffin block specimens by DNA index and synthetic phase fraction (SPF) would be of prognostic value, a retrospective chart review of 14 patients with carotid body tumors was performed. Three of 14 tumors were aneuploid and were the only tumors with SPF >15%. One of 3 patients (33%) with an aneuploid tumor (SPF=22%) developed a local recurrence; no patient with a diploid tumor developed a recurrence. Two of 3 (67%) patients with aneuploid tumors (SPF=18%) but only 1 of 11 (9%) with a diploid tumor were symptomatic preoperatively (P = 0.03). DNA index and SPF may help select a subgroup of patients with more aggressive tumors who are at increased risk for recurrence and therefore require closer follow-up.
Keyword Carotid body
DNA index
Synthetic phase fraction (SPF)
Tumors
Cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 19 July 2006.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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