Low-dose cyclophosphamide enhances helper-to-non-helper ratios

Sardi, A., Agnone, C., Anderson, G., Bolton, J.S., Sundgaard-Riise, K., Nieroda, C and Minton, J.P. (1991) Low-dose cyclophosphamide enhances helper-to-non-helper ratios. Cancer Detection and Prevention, 15 3: 217-224.

Author Sardi, A.
Agnone, C.
Anderson, G.
Bolton, J.S.
Sundgaard-Riise, K.
Nieroda, C
Minton, J.P.
Title Low-dose cyclophosphamide enhances helper-to-non-helper ratios
Journal name Cancer Detection and Prevention   Check publisher's open access policy
ISSN 0361-090X
Publication date 1991
Sub-type Article (original research)
Volume 15
Issue 3
Start page 217
End page 224
Total pages 8
Place of publication New York, NY, United States
Publisher New York, NY 10010 United States
Language eng
Abstract This study was conducted to analyze the effect of different doses of cyclophosphamide (CY) on the lymphocyte populations in the rat. Monoclonal antibodies against rat determinants were used: W3/13 (T lymphocytes), W3/25 (T helper), OX-8 (non-helper), and OX-33 (B lymphocytes). Blood samples were collected on days 0, 3, 7, and 14 from four groups of F-344 Fisher rats (n = 4): three that received 25, 50, or 75 mg/kg of CY and a control group. The duration and severity of lymphocyte depletion were dose-related and were evident for both helper and non-helper cells (p less than 0.02). The helper-to-non-helper ratio increased for the group that received 25 mg/kg when compared with control and other groups, but was only significantly changed when compared with the 75 mg/kg group (p = 0.004). This effect was transitory and was only seen on day 3. The control and the 25 mg/kg groups gained weight; the other two groups lost weight (p less than 0.05). Lower doses of CY were associated with a transitory immunostimulatory effect and no morbidity when compared with higher doses.
Keyword Immunostimulation
Chemotherapeutic agents
Lymphocyte subsets
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Mon, 14 Mar 2011, 10:52:09 EST