Understanding patterns of failure in breast cancer treatment argues for a more thorough investigation of axillary lymph nodes in node negative patients

Brand, T. C., Sawyer, M. M., King, T. A., Bolton, J. S. and Fuhrman, G. M. (2000). Understanding patterns of failure in breast cancer treatment argues for a more thorough investigation of axillary lymph nodes in node negative patients. In: 52nd Annual Meeting of the Southwestern Surgical Congress, Colorado Springs, CO, United States, (424-427). 9-12 April 2000. doi:10.1016/S0002-9610(00)00507-9


Author Brand, T. C.
Sawyer, M. M.
King, T. A.
Bolton, J. S.
Fuhrman, G. M.
Title of paper Understanding patterns of failure in breast cancer treatment argues for a more thorough investigation of axillary lymph nodes in node negative patients
Conference name 52nd Annual Meeting of the Southwestern Surgical Congress
Conference location Colorado Springs, CO, United States
Conference dates 9-12 April 2000
Journal name American Journal of Surgery   Check publisher's open access policy
Publisher Elsevier
Publication Year 2000
Sub-type Fully published paper
DOI 10.1016/S0002-9610(00)00507-9
ISSN 0002-9610
1879-1883
Volume 180
Issue 6
Start page 424
End page 427
Total pages 3
Language eng
Abstract/Summary BACKGROUND: An understanding of the patterns of failure after potentially curative treatment of breast cancer patients can lead to the development of improved methods of patient management. METHODS: We compared two groups of patients in whom breast cancer recurred after potentially curative treatment. Patients were assigned to their groups based on the status of their lymph nodes at the time of presentation. RESULTS: In all, 294 recurrences were analyzed to demonstrate that the patterns of failure for the two groups were identical. In the node-positive group, recurrence occurred sooner and their primary tumors were larger. CONCLUSIONS: The nearly identical patterns of treatment failure in lymph node negative and positive breast cancer patients suggests that metastasis in node negative patients occurs by a similar mechanism. The shorter time to recurrence and larger primary tumor may only reflect a lead time bias, in that node-positive patients have a greater tumor burden in their lymph nodes that facilitates identification by pathologists.
Keyword ADJUVANT SYSTEMIC THERAPY
MICROMETASTASES
MACROMETASTASES
MASTECTOMY
CARCINOMA
TRIAL
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:49:44 EST