Intraperitoneal povidone-iodine in experimental canine and murine peritonitis

Bolton, John S., Bornside, George H. and Cohn Jr, Isidore (1979) Intraperitoneal povidone-iodine in experimental canine and murine peritonitis. American Journal of Surgery, 137 6: 780-785. doi:10.1016/0002-9610(79)90093-X

Author Bolton, John S.
Bornside, George H.
Cohn Jr, Isidore
Title Intraperitoneal povidone-iodine in experimental canine and murine peritonitis
Journal name American Journal of Surgery   Check publisher's open access policy
ISSN 0002-9610
Publication date 1979-06
Sub-type Article (original research)
DOI 10.1016/0002-9610(79)90093-X
Volume 137
Issue 6
Start page 780
End page 785
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Abstract In dogs with appendicitis-peritonitis, intraperitoneal povidone-iodine caused death more rapidly than the instillation of saline solution. The bacterial content of canine peritoneal fluid increased with time. Although fewer bacteria were found in fluid from povidone-iodine-treated dogs, the differences were not statistically significant. Qualitative chemical analysis of peritoneal fluid revealed iodide, but not free iodine, 15 to 30 minutes after instillation of povidone-iodine. Iodide was present in the peritoneum at 2 hours but not at 3 or 6 hours. The antibacterial effect of povidone-iodine was demonstrated in mice challenged intraperitoneally with lethal doses of Escherichia coli. Povidone-iodine diminished mortality when injected immediatly (p<0.005) but not when given 1 to 3 hours later. Immediate injection of povidone-iodine into mice lowered the number of E. coli by only 1/3 log. This lesser bactericidal effect in mice is attributed to greater dispersal and sequestration of bacteria throughout the peritoneal cavity with time and with inactivation of povidone-iodine by reduction to iodide in vivo. In dogs with appendicitis-peritonitis, the more rapid death after treatment with povidone-iodine was not associated with differences in peritoneal microflora but with peritoneal absorption of excessive amounts of iodide.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Mon, 14 Mar 2011, 10:49:12 EST