Circulating immunoreactive interleukin-6 in cystic fibrosis

Nixon, Lisette S., Yung, Bernard, Bell, Scott C., Elborn, J.Stuart and Shale, Dennis J. (1998) Circulating immunoreactive interleukin-6 in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, 157 6: 1764-1769.

Author Nixon, Lisette S.
Yung, Bernard
Bell, Scott C.
Elborn, J.Stuart
Shale, Dennis J.
Title Circulating immunoreactive interleukin-6 in cystic fibrosis
Journal name American Journal of Respiratory and Critical Care Medicine   Check publisher's open access policy
ISSN 1073-449X
Publication date 1998-06
Sub-type Article (original research)
Volume 157
Issue 6
Start page 1764
End page 1769
Total pages 6
Place of publication New York, NY, United States
Publisher American Thoracic Society
Language eng
Formatted abstract
We measured circulating and sputum-sol concentrations of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), neutrophil elastase-α1-antiproteinase complex (NEAPC), and C-reactive protein (CRP) in an exacerbation, after antibiotic treatment, and in clinically stable patients with cystic fibrosis and chronic pulmonary infection with Pseudomonas aeruginosa. The aim was to determine the compartmental patterns of a proinflammatory and anti-inflammatory cytokine compared with other markers of inflammatory activity in cystic fibrosis. IL-6, NEAPC, CRP, and absolute neutrophil count were reduced after antibiotic treatment, p < 0.01. IL-6 and CRP concentrations were greater, p = 0.007, and p = 0.01, respectively, in a stable group of patients compared with those at the end of an exacerbation. IL-6 and CRP concentrations were related (r = 0.836, p < 0.0001), and both were greater than in matched control subjects (p < 0.001) at all times studied. Sputum-sol concentrations of IL-6 after treatment were positively related to FEV1 and FVC and inversely related to concentrations of neutrophil elastase. The separation between patients and healthy subjects, and the reduction of IL-6 after antibiotic treatment indicates it could be used as a marker of inflammation, but its relationship toother markers depends on the compartment in which it is measured.
Keyword Tumor necrosis factor
Factor alpha
Lung disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Pediatric Pulmonary and Cystic Fibrosis

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Mon, 14 Mar 2011, 10:46:57 EST