Evidence for opioid modulation and generation of prostaglandins in sulphur dioxide (SO)(2)-induced bronchoconstriction

Field, Penelope I., Simmul, Rein, Bell, Scott C., Allen, David H. and Berend, Norbert (1996) Evidence for opioid modulation and generation of prostaglandins in sulphur dioxide (SO)(2)-induced bronchoconstriction. Thorax, 51 2: 159-163. doi:10.1136/thx.51.2.159


Author Field, Penelope I.
Simmul, Rein
Bell, Scott C.
Allen, David H.
Berend, Norbert
Title Evidence for opioid modulation and generation of prostaglandins in sulphur dioxide (SO)(2)-induced bronchoconstriction
Journal name Thorax   Check publisher's open access policy
ISSN 0040-6376
1468-3296
Publication date 1996-02
Sub-type Article (original research)
DOI 10.1136/thx.51.2.159
Volume 51
Issue 2
Start page 159
End page 163
Total pages 5
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Formatted abstract
Background -
Inhalation of sulphur dioxide (SO2) provokes bronchoconstriction in asthmatic subjects. Cholinergic mechanisms contribute, but other mechanisms remain undefined. The effect of morphine, an opioid agonist, on the cholinergic component of SO2-induced bronchoconstriction was investigated, and the effect of indomethacin, a cyclooxygenase inhibitor, on SO2-induced bronchoconstriction and tachyphylaxis was studied.

Methods -
In the first study 16 asthmatic subjects inhaled either ipratropium bromide or placebo 60 minutes before an SO2 challenge on days 1 and 2. On day 3 an SO2 challenge was performed immediately after intravenous morphine. In the second study 15 asthmatic subjects took either placebo or indomethacin for three days before each study day when two SO2 challenges were performed 30 minutes apart. The response was measured as the cumulative dose causing a 35% fall in specific airways conductance (sGaw; PDsGaw35).

Results -
Ipratropium bromide significantly inhibited SO2 responsiveness, reducing PDsGaW35 by 0.89 (95% CI 0.46 to 1.31) doubling doses. This effect persisted after correction for bronchodilatation induced by ipratropium bromide. The effect of ipratropium bromide and morphine on SO, responsiveness also correlated (r2= 0.71). In the second study SO2 tachyphylaxis developed with PDsGaw35 on repeated testing, being reduced by 0.62 (95% CI 0.17 to 1.07) doubling doses. Indomethacin attenuated baseline SO2 responsiveness, increasing PDsGaw35 by 0.5 (95% CI 0.06 to 0.93) doubling doses.

Conclusions -

These results suggest that opioids modulate the cholinergic component of SO, responsiveness and that cyclooxygenase products contribute to the immediate response to SO2.
Keyword Sulphur dioxide
Bronchoconstriction
Asthma
Mechanisms
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:46:17 EST