Laser angioplasty: An atherosclerotic swine model

White, Christopher J., Ramee, Stephen R., Card, Hal G., Abrahams, Lisa A., Svinarich, J. Thomas, Wade, Charles E., Rodkey, William G. and Virmani, Renu (1988) Laser angioplasty: An atherosclerotic swine model. Lasers in Surgery and Medicine, 8 3: 318-321. doi:10.1002/lsm.1900080315


Author White, Christopher J.
Ramee, Stephen R.
Card, Hal G.
Abrahams, Lisa A.
Svinarich, J. Thomas
Wade, Charles E.
Rodkey, William G.
Virmani, Renu
Title Laser angioplasty: An atherosclerotic swine model
Journal name Lasers in Surgery and Medicine   Check publisher's open access policy
ISSN 0196-8092
Publication date 1988
Sub-type Other
DOI 10.1002/lsm.1900080315
Volume 8
Issue 3
Start page 318
End page 321
Total pages 4
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Rapid production of occlusive, atherosclerotic iliac artery lesions was achieved in 25 of 27 (93%) Yucatan miniature swine, using a combination of high cholesterol diet and mechanical endothelial denudation. Animals were fed a diet with 2% of their calories as raw cholesterol 2 weeks prior to balloon denudation of iliac arteries, which resulted in atherosclerotic lesions within 8 weeks. Early after denudation we have demonstrated total occlusion of arteries by fibrin thrombi, which in time organize and ultimately result in fibrotic occlusive disease. The arterial walls and intima show varying degrees of foam cell infiltration with destruction of the internal elastic lamina and calcification. Totally occluded lesions show fibrointimal proliferation, fibrosis, and multiluminal channels, which are probably secondary to organized thrombus. Our model of occlusive iliac artery disease involving vessels of 1 to 3 mm in diameter allows the development of catheter systems suitable for use in human peripheral and coronary arteries. This model is useful for the study of angioplasty, whether mechanical, balloon, or laser-mediated.
Keyword Laser
Angioplasty
Swine
Atherosclerosis
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Other
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:32:17 EST