Objectivebenefit of nifedipine in the treatment of Raynaud's phenomenon: Double-blind controlled study

White, Christopher J., Phillips, William A., Abrahams, Lisa A., Watson, Thomas D. and Singleton, Peter T. (1986) Objectivebenefit of nifedipine in the treatment of Raynaud's phenomenon: Double-blind controlled study. American Journal of Medicine, 80 4: 623-625. doi:10.1016/0002-9343(86)90817-X


Author White, Christopher J.
Phillips, William A.
Abrahams, Lisa A.
Watson, Thomas D.
Singleton, Peter T.
Title Objectivebenefit of nifedipine in the treatment of Raynaud's phenomenon: Double-blind controlled study
Journal name American Journal of Medicine   Check publisher's open access policy
ISSN 0002-9343
Publication date 1986-04-01
Sub-type Article (original research)
DOI 10.1016/0002-9343(86)90817-X
Volume 80
Issue 4
Start page 623
End page 625
Total pages 3
Place of publication Bridgewater, NJ, United States
Publisher Excerpta Medica
Language eng
Abstract To compare the effects of the calcium channel antagonist, nifedipine, with that of placebo, a randomized double-blind crossover study was performed in 11 patients with moderate to severe Raynaud's phenomenon. Digital skin temperature recovery time was measured after immersing the patient's hand in ice water for 20 seconds. Patients were randomly assigned to receiving either nifedipine or placebo for one week, followed by the crossover phase. Skin temperature recovery time was also measured in 21 normal volunteers. The mean time to recovery for patients taking nifedipine was 28.5 ± 20.8 minutes versus 44.9 ± 18.9 minutes for patients receiving placebo (p <0.05 by analysis of variance with repeated measures). The mean time to recovery for the normal volunteers was 11.3 ± 7.2 minutes versus 40.2 ± 19.9 minutes for the patients (p <0.01 by the Student t test). Nine of the 11 patients noted improvement of symptoms during treatment with nifedipine. It is concluded that nifedipine is an effective, well-tolerated treatment for Raynaud's phenomenon.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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