Hormonal and renal responses to converting enzyme inhibition during maximal exercise

Wade, C. E., Ramee, S. R., Hunt, M. M. and White, C. J. (1987) Hormonal and renal responses to converting enzyme inhibition during maximal exercise. Journal of Applied Physiology, 63 5: 1796-1800.

Author Wade, C. E.
Ramee, S. R.
Hunt, M. M.
White, C. J.
Title Hormonal and renal responses to converting enzyme inhibition during maximal exercise
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
1522-1601
Publication date 1987-11-01
Sub-type Article (original research)
Volume 63
Issue 5
Start page 1796
End page 1800
Total pages 5
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Formatted abstract
The role of angiotensin II in the hormonal and renal responses to maximal exercise was investigated by using the angiotensin-converting enzyme inhibitor captopril. Nine male subjects performed a standardized maximal treadmill test with and without acute captopril treatment (25 mg orally). At rest, captopril elevated plasma renin activity and lowered aldosterone levels. With maximal exercise, captopril treatment reduced the increase in mean arterial blood pressure by 8 mmHg and the increase in plasma renin activity by 3.0 ng ANG I·ml -1·h -1. The responses of adrenocorticotropin (ACTH), cortisol, and vasopressin to maximal exercise were not altered by captopril treatment. Although aldosterone levels were reduced at rest with captopril, during maximal exercise no difference was noted between treatments. Captopril treatment had no effects on the renal handling of salts or water during exercise. In conclusion, angiotensin II plays a role in the increase in mean blood pressure during maximal exercise in normal subjects but has no effect on the exercise responses of ACTH, vasopressin, and aldosterone or on the renal handling of salts and water.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Mon, 14 Mar 2011, 20:30:07 EST