Influence of donor and recipient gender on cardiac allograft vasculopathy: An intravascular ultrasound study

Mehra, M. R., Stapleton, D. D., Ventura, H. O., Escobar, A., Cassidy, C. A., Smart, F. W., Collins, T. J., Ramee, S. R. and White, C. J. (1994) Influence of donor and recipient gender on cardiac allograft vasculopathy: An intravascular ultrasound study. Circulation, 90 5: 78-82.

Author Mehra, M. R.
Stapleton, D. D.
Ventura, H. O.
Escobar, A.
Cassidy, C. A.
Smart, F. W.
Collins, T. J.
Ramee, S. R.
White, C. J.
Title Influence of donor and recipient gender on cardiac allograft vasculopathy: An intravascular ultrasound study
Journal name Circulation   Check publisher's open access policy
ISSN 0009-7322
1524-4539
Publication date 1994-11
Sub-type Article (original research)
Volume 90
Issue 5
Start page 78
End page 82
Total pages 5
Place of publication Baltimore, MD, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Background: Cardiac allograft vasculopathy remains the leading limitation to long-term survival after cardiac transplantation. While the influence of donor and recipient gender in the pathogenesis of cardiac vasculopathy is still poorly understood, studies have indicated that female allografts may be at higher risk for the development of cardiac allograft vasculopathy. The purpose of this study was to characterize the influence of donor and recipient gender on the early genesis of cardiac allograft vasculopathy by using intravascular ultrasound.
Methods and Results: Thirty-six consecutive cardiac transplant recipients were divided into three groups on the basis of donor and recipient gender as follows: group 1, female donor and male recipient (n=8); group 2, male donor and female recipient (n=7); and group 3, male donor and male recipient (n=21). The three groups were similar with regard to donor and recipient age, weight, body surface area, serum lipids, left ventricular function, histocompatibility, cellular and vascular rejection, and cytomegalovirus infection. To precisely quantitate the extent of cardiac allograft vasculopathy, intravascular ultrasound was performed in all patients at the time of first annual angiography. Intimal thickening and intimal index were accurately quantitated by intravascular ultrasound. Intimal thickening was significantly greater in group 1 (0.55±0.15 mm) than in group 2 (0.18±0.04 mm) or group 3 (0.29±0.05 mm) (P<.05). In addition, the intimal index was greater in group 1 (0.20±0.04) than in group 2 (0.07±0.02) or group 3 (0.15±0.02) (P<.01, group 1 versus group 2).
Conclusions: Male recipients of female allografts have a higher degree of vascular intimal hyperplasia detected by intravascular ultrasound at 1 year after heart transplantation. These findings indicate that donor and recipient gender influences the early genesis of cardiac allograft vasculopathy.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:24:49 EST