Endovascular therapy for critical limb ischemia

Arain, Salman A. and White, Christopher J. (2008) Endovascular therapy for critical limb ischemia. Vascular Medicine, 13 3: 267-279. doi:10.1177/1358863X07087129

Author Arain, Salman A.
White, Christopher J.
Title Endovascular therapy for critical limb ischemia
Journal name Vascular Medicine   Check publisher's open access policy
ISSN 1358-863X
Publication date 2008-08
Sub-type Article (original research)
DOI 10.1177/1358863X07087129
Open Access Status Not Open Access
Volume 13
Issue 3
Start page 267
End page 279
Total pages 13
Place of publication London, United Kingdom
Publisher Sage
Language eng
Abstract Chronic critical limb ischemia (CLI) occurs when arterial perfusion is reduced below a threshold level that results in rest pain and/or tissue breakdown in the lower extremities. Importantly, it is associated with high cardiovascular morbidity and mortality. Without prompt revascularization, CLI may result in loss of a limb (i.e. amputation) and/or life. The goal of endovascular therapy is the re-establishment of pulsatile, straight-line flow to the distal extremity. Percutaneous transluminal angioplasty (PTA) has been shown to be effective and safe in the setting of CLI, with limb salvage rates that compare favorably with surgical procedures. Stents are indicated for failed PTA, while adjunctive therapies such as lasers, thermal angioplasty and atherectomy devices lack data demonstrating improved efficacy compared with conventional lower extremity interventions. In addition to successful revascularization, the institution of lifestyle changes, atherosclerotic risk factor modification, and pharmacologic therapies are indicated to reduce cardiovascular morbidity and mortality.
Keyword angioplasty
peripheral arterial disease
rest pain
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 14 Mar 2011, 10:20:10 EST