Impaired systemic arterial compliance in borderline hypertension

Ventura, Hector, Messerli, Franz H., Oigman, Wille, Suarez, Daniel H., Dreslinski, Gerald R., Dunn, Francis G., Reisin, Efrain and Frohlich, Edward D. (1984) Impaired systemic arterial compliance in borderline hypertension. American Heart Journal, 108 1: 132-136. doi:10.1016/0002-8703(84)90555-6

Author Ventura, Hector
Messerli, Franz H.
Oigman, Wille
Suarez, Daniel H.
Dreslinski, Gerald R.
Dunn, Francis G.
Reisin, Efrain
Frohlich, Edward D.
Title Impaired systemic arterial compliance in borderline hypertension
Journal name American Heart Journal   Check publisher's open access policy
ISSN 0002-8703
Publication date 1984
Sub-type Article (original research)
DOI 10.1016/0002-8703(84)90555-6
Volume 108
Issue 1
Start page 132
End page 136
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Abstract Arterial compliance was evaluated by pulse wave velocity, pulse pressure/stroke volume, and by an exponential analysis of the diastolic blood pressure decay curve in three groups of normotensive, borderline hypertensive, and established essential hypertensive patients. Two of the above three indices reflected significantly impaired arterial compliance in borderline hypertension, and all three indices were distinctly abnormal in patients with established hypertension. A close correlation among the three indices was observed in the entire study population. Multiple regressive analysis indicated that age (p < 0.005), systolic (p < 0.005) and diastolic (p < 0.025) pressure were independent determinants of pulse wave velocity; other factors such as total peripheral resistance, pulse pressure, and stroke volume were not. We conclude that arterial compliance becomes impaired early in hypertensive cardiovascular disease at the time when arterial pressure may be only slightly elevated. Thus structural alteration of the arterial wall can be demonstrated in borderline hypertension. Age, systolic and, to a lesser degree, diastolic pressures are the best determinants of arterial compliance in large vessels and are therefore important risk factors for evolving systemic arterial disease in essential hypertension.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Mon, 14 Mar 2011, 10:18:58 EST