Treatment of heart failure according to William Stokes: The enchanted mercury

Ventura, Hector O., Mehra, Mandeep R. and Young, James B. (2001) Treatment of heart failure according to William Stokes: The enchanted mercury. Journal of Cardiac Failure, 7 3: 277-282. doi:10.1054/jcaf.2001.26564

Author Ventura, Hector O.
Mehra, Mandeep R.
Young, James B.
Title Treatment of heart failure according to William Stokes: The enchanted mercury
Journal name Journal of Cardiac Failure   Check publisher's open access policy
ISSN 1071-9164
Publication date 2001-09
Sub-type Article (original research)
DOI 10.1054/jcaf.2001.26564
Volume 7
Issue 3
Start page 277
End page 282
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Churchill Livingstone
Language eng
Formatted abstract
Background: It was not until 1919 that the diuretic properties of mercury were observed in patients with syphilis; in the same year the beneficial effects of mercurial diuretics were shown in a patient with severe rheumatic heart disease and anasarca. However, mercury had been used much earlier for the treatment of dropsy without clear guidelines. In this article we describe William Stokes' insights into the treatment of heart failure, focusing on the beneficial diuretic properties of mercury.

Methods: We reviewed the chapter "Treatment of the Weak and Probably Dilated Heart in Connexion With Enlargement of the Liver and Pulmonary Disease" in William Stokes' famous treatise The Diseases of the Heart and the Aorta.

Conclusions: Stokes makes several important clinical observations. First, he provides precise guidelines on when and how to use mercury in these patients. Second, he realizes the importance of mercury for the treatment of decompensated heart failure. Stokes recognizes the cyclical nature of frequent decompensation in congestive heart failure, the relationship of clinical deterioration and reduced urine output, and the importance of reestablishing urinary flow to ameliorate dyspnea. Third, he attempts to define the mechanism of action ". . . if any of the characteristic action of mercury can be perceived unless we include diuresis." Finally, he gives interesting guidelines on the dosage and side effects of mercury. These observations on the treatment of "congestive" heart failure are an important contribution to the understanding of heart failure pathophysiology and the design of prescription regimens for this disease.
Keyword Diuretics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 14 Mar 2011, 10:17:49 EST