Cardiac adaptation to obesity and hypertension after heart transplantation

Ventura, Hector O., Johnson, Maryl R., Grusk, Bonnie, Pifarre, Roque and Costanzo-Nordin, Maria Rosa (1992) Cardiac adaptation to obesity and hypertension after heart transplantation. Journal of the American College of Cardiology, 19 1: 55-59.


Author Ventura, Hector O.
Johnson, Maryl R.
Grusk, Bonnie
Pifarre, Roque
Costanzo-Nordin, Maria Rosa
Title Cardiac adaptation to obesity and hypertension after heart transplantation
Journal name Journal of the American College of Cardiology   Check publisher's open access policy
ISSN 0735-1097
Publication date 1992-01
Sub-type Article (original research)
Volume 19
Issue 1
Start page 55
End page 59
Total pages 5
Place of publication San Diego, CA, United States
Publisher Elsevier
Language eng
Formatted abstract
Obesity and hypertension frequently develop after heart transplantation. The cardiac adaptation to obesity and hypertension was studied by determining hemodynamic and echocardiographic indexes in 10 obese hypertensive patients (body mass index ≥27.8 kg/m2 in men or ≥ 27.3 kg/m2 in women) matched by mean arterial pressure, age and gender with 10 nonobese hypertensive patients 1 year after cardiac transplantation. Cardiac output was 30% greater (p < 0.02) and systemic vascular resistance 25% lower (p < 0.01) in the obese than in the nonobese patients. Right ventricular systolic and pulmonary artery systolic, diastolic and mean pressures were also significantly higher (p < 0.05) in the obese patients. Left ventricular end-diastolic diameter was 25% greater (p < 0.05), left ventricular mass 28% greater (p < 0.02) and left ventricular end-diastolic volume 20% higher (p < 0.01) in the obese subjects. Left ventricular ejection fraction was significantly lower in the obese than in the nonobese subjects (34% vs. 51%, p < 0.05).

These results indicate that the cardiac adaptation to obesity and hypertension after heart transplantation consists of left ventricular dilation and an increase in left ventricular mass associated with an increased cardiac output and lower peripheral vascular resistance. These adaptive changes that occur in obese hypertensive patients after heart transplantation might increase the long-term risk of graft failure, as suggested by their lower left ventricular ejection fraction 1 year after transplantation.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:16:41 EST