Immediate regional blood flow distribution following angiotensin converting enzyme inhibition in patients with essential hypertension

Ventura, Hector O., Frohlich, Edward D., Messerli, Franz H., Kobrin, Isaac and Kardon, Merrill B. (1984) Immediate regional blood flow distribution following angiotensin converting enzyme inhibition in patients with essential hypertension. American Journal of Medicine, 76 5B: 58-61. doi:10.1016/0002-9343(84)90885-4


Author Ventura, Hector O.
Frohlich, Edward D.
Messerli, Franz H.
Kobrin, Isaac
Kardon, Merrill B.
Title Immediate regional blood flow distribution following angiotensin converting enzyme inhibition in patients with essential hypertension
Journal name American Journal of Medicine   Check publisher's open access policy
ISSN 0002-9343
1555-7162
Publication date 1984
Sub-type Article (original research)
DOI 10.1016/0002-9343(84)90885-4
Volume 76
Issue 5B
Start page 58
End page 61
Total pages 4
Place of publication Bridgewater, NJ, United States
Publisher Excerpta Medica
Language eng
Abstract The increased total peripheral resistance that characterizes essential hypertension is generally reversed by antihypertensive drugs, but the reduction may not be uniform in all regions of the body. In this study, regional blood flow was investigated immediately after the oral administration of 25 mg of captopril in 11 patients with mild to moderate essential hypertension. Within 90 minutes, the total vascular resistance decreased significantly, and the decrease was significant in the kidney. It decreased but not significantly in the splanchnic organs, the skeletal musculature, and the skin. In no region was the blood flow reduced. As captopril has no direct effect on smooth muscle, these effects are likely to have been due to angiotensin converting enzyme inhibition.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:16:33 EST