Borderline hypertension and obesity: Two prehypertensive states with elevated cardiac output

Messerli, Franz H., Ventura, Hector O., Reisin, Efrain, Dreslinski, Gerald R., Dunn, Francis G., MacPhee, Allan A. and Frochlich, Edward D. (1982) Borderline hypertension and obesity: Two prehypertensive states with elevated cardiac output. Circulation, 66 1: 55-60.

Author Messerli, Franz H.
Ventura, Hector O.
Reisin, Efrain
Dreslinski, Gerald R.
Dunn, Francis G.
MacPhee, Allan A.
Frochlich, Edward D.
Title Borderline hypertension and obesity: Two prehypertensive states with elevated cardiac output
Journal name Circulation   Check publisher's open access policy
ISSN 0009-7322
Publication date 1982
Sub-type Article (original research)
Volume 66
Issue 1
Start page 55
End page 60
Total pages 6
Place of publication Baltimore, MD United States
Publisher Lippincott Williams and Wilkins
Language eng
Formatted abstract
Systemic, renal and splanchnic hemodynamics, intravascular volume, circulating catecholamine levels and plasma renin activity were compared in 39 patients with borderline hypertension and 28 normotensive subjects, who were less than 5% (n = 42, lean patients) or more than 40% overweight (n = 25, obese patients). Lean borderline hypertensive patients had greater cardiac output (p < 0.05), heart rate (p < 0.01) and renal blood flow (p < 0.05); cardiopulmonary redistribution of intravascular volume (p < 0.05); and higher circulating norepinephrine levels (p < 0.05). Obese normotensive subjects also showed an increased cardiac output (p < 0.005), stroke volume (p < 0.01), left ventricular stroke work (p < 0.05), and renal blood flow (p < 0.05) (but not respective indexes), but intravascular volume was expanded (p < 0.05) without redistribution and circulating catecholamine levels were normal. Obese borderline hypertensive patients had hemodynamic characteristics similar to those of obese normotensive subjects except for an increased peripheral resistance (p < 0.05). The data indicate that although both populations have an increased cardiac output, the lean borderline hypertensive patients have signs of enhanced adrenergic activity as evidenced by higher circulating catecholamine levels and heart rate with blood volume translocation to the cardiopulmonary circulation. In contrast, the obese subjects (whether normotensive or borderline hypertensive), who also have increased cardiac output, seem to have normal adrenergic activity and an expanded intravascular volume without cardiopulmonary redistribution.
Keyword Borderline Hypertension
Cardiovascular Disease
Heart Output
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Mon, 14 Mar 2011, 10:13:02 EST