Hypertension and sudden death increased ventricular ectopic activity in left ventricular hypertrophy

Messerli, Franz H., Ventura, Hector O., Elizardi, David J., Dunn, Francis G. and Frohlich, Edward D. (1984) Hypertension and sudden death increased ventricular ectopic activity in left ventricular hypertrophy. American Journal of Medicine, 77 1: 18-22. doi:10.1016/0002-9343(84)90430-3


Author Messerli, Franz H.
Ventura, Hector O.
Elizardi, David J.
Dunn, Francis G.
Frohlich, Edward D.
Title Hypertension and sudden death increased ventricular ectopic activity in left ventricular hypertrophy
Journal name American Journal of Medicine   Check publisher's open access policy
ISSN 0002-9343
1555-7162
Publication date 1984
Sub-type Article (original research)
DOI 10.1016/0002-9343(84)90430-3
Volume 77
Issue 1
Start page 18
End page 22
Total pages 5
Place of publication Bridgewater, NJ, United States
Publisher Excerpta Medica
Language eng
Abstract The present study was designed to detect and quantify cardiac arrhythmias in hypertensive patients with left ventricular hypertrophy. Continuous ambulatory electrocardiographic tracings and arterial pressure were recorded for 24 hours in 14 normotensive subjects, 10 patients with established essential hypertension without left ventricular hypertrophy, and 16 hypertensive patients with left ventricular hypertrophy by electrocardiographic criteria. Urinary excretion of norepinephrine was simultaneously measured over four successive four-hour and one eight-hour period. Patients with left ventricular hypertrophy had significantly more ventricular (but not atrial) premature contractions than those without left ventricular hypertrophy or than normotensive subjects. Five patients with left ventricular hypertrophy had episodes of more than 30 premature ventricular contractions per minute. Higher-grade ventricular ectopic activity such as coupled premature ventricular contractions was seen in two, and multifocal premature ventricular contractions were seen in three in the group with left ventricular hypertrophy. No difference in urinary catecholamine excretion rates among the three groups was seen. Left ventricular hypertrophy has been shown to be an independent risk factor for sudden death and acute myocardial infarction. Electrocardiographic monitoring of patients with left ventricular hypertrophy allows identification of those who have the highest risk and, therefore, require the most aggressive therapeutic intervention.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 486 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 392 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 14 Mar 2011, 10:12:54 EST