Cardiac allograft vasculopathy in the elderly heart transplant recipient

Mehra, M. R., Ventura, H. O., Stapleton, D. D., Dumas, D. H. and Smart, F. W. (1996) Cardiac allograft vasculopathy in the elderly heart transplant recipient. Cardiology in the Elderly, 4 1: 22-27.

Author Mehra, M. R.
Ventura, H. O.
Stapleton, D. D.
Dumas, D. H.
Smart, F. W.
Title Cardiac allograft vasculopathy in the elderly heart transplant recipient
Journal name Cardiology in the Elderly
ISSN 1058-3661
Publication date 1996-02
Sub-type Critical review of research, literature review, critical commentary
Volume 4
Issue 1
Start page 22
End page 27
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract Advances in immunosuppression have improved the early survival of heart transplant recipients, but cardiac allograft vasculopathy (accelerated graft atherosclerosis) is the leading cause of graft loss after the first year of transplantation. In this review we discuss recent developments in our understanding of cardiac allograft vasculopathy with particular reference to the elderly heart transplant recipient, As both donor age and recipient age are potential risk factors in heart transplantation, it is only prudent to examine their disparate impact on development of this disease process, Available observational studies using angiography and ultrasound for the clinical detection of cardiac allograft vasculopathy suggest that older age does not predispose to the development of this disease. However, recipients of older allografts might be at increased risk of development of prognostically relevant allograft intimal proliferation. This group of heart transplant recipients may need closer monitoring and more aggressive risk-factor modification.
Keyword Allograft
Atherosclerosis
Vasculopathy
Age
Intravascular ultrasound
Transplantation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:11:54 EST