New developments in the diagnosis and management of cardiac allograft vasculopathy

Mehra, M. R., Ventura, H. O., Smart, F. W., Stapleton, D. D., Collins, T. J., Ramee, S. R., Murgo, J. P. and White, C. J. (1995) New developments in the diagnosis and management of cardiac allograft vasculopathy. Texas Heart Institute Journal, 22 2: 138-144.

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Author Mehra, M. R.
Ventura, H. O.
Smart, F. W.
Stapleton, D. D.
Collins, T. J.
Ramee, S. R.
Murgo, J. P.
White, C. J.
Title New developments in the diagnosis and management of cardiac allograft vasculopathy
Journal name Texas Heart Institute Journal   Check publisher's open access policy
ISSN 0730-2347
1526-6702
Publication date 1995
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 22
Issue 2
Start page 138
End page 144
Total pages 7
Place of publication Houston, TX, United States
Publisher Texas Heart Institute
Language eng
Abstract The major cause of late death in cardiac transplant recipients is cardiac allograft vasculopathy, also referred to as cardiac transplant atherosclerosis, which occurs in as many as 45% of transplant recipients who survive longer than 1 year. It differs from typical atherosclerosis in that intimal hyperplasia is concentric and diffuse, the internal elastic lamina remains intact, calcification is rare, and the disease tends to develop rapidly. Intravascular ultrasound and coronary angioscopy are more sensitive diagnostic measures of cardiac allograft vasculopathy than is coronary angiography. Although retransplantation at present seems to be the only definitive therapy for cardiac allograft vasculopathy, it has shown only fair results. Recent studies have suggested that calcium entry blockers and angiotensin-converting enzyme inhibitors may play a beneficial role in delaying the progression of cardiac allograft vasculopathy.
Keyword Angioplasty
Coronary vessels/ultrasonography
Graft occlusion
Vascular
Transplantation
Homologous
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:11:50 EST