Immunosuppressive therapy in the elderly heart transplant recipient

Kapoor, C., Mehra, M. R., Ventura, H. O., Stapleton, D. D. and Smart, F. W. (1996) Immunosuppressive therapy in the elderly heart transplant recipient. Cardiology in the Elderly, 4 1: 11-14.

Author Kapoor, C.
Mehra, M. R.
Ventura, H. O.
Stapleton, D. D.
Smart, F. W.
Title Immunosuppressive therapy in the elderly heart transplant recipient
Journal name Cardiology in the Elderly   Check publisher's open access policy
ISSN 1058-3661
Publication date 1996-02
Sub-type Critical review of research, literature review, critical commentary
Volume 4
Issue 1
Start page 11
End page 14
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract In the early years of cardiac transplantation, age above 55 years was an absolute contraindication to heart transplant. The introduction of cyclosporine and advances in surgical technique brought about a dramatic improvement in the survival of cardiac transplant recipients. The use of cyclosporine allowed corticosteroid doses to be reduced, which resulted in a decreased incidence of infections and metabolic abnormalities. At many centers, the upper age limit for cardiac transplant recipients has been raised to 70 years. The increasing number of elderly heart transplant recipients requires us to revise our strategy for immunosuppressive therapy in this cohort, as they are immunologically deficient when compared with younger recipients. in this article we describe the various immunosuppressive therapies available and their side-effects, with a particular focus on tailoring therapy for the elderly heart transplant recipient.
Keyword Elderly
Immunosuppression
Heart transplantation
Allograft rejection
Allograft vasculopathy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:09:24 EST