Enalapril improves systemic and renal hemodynamics and allows regression of left ventricular mass in essential hypertension

Dunn, Francis G., Oigman, Wille, Ventura, Hector O., Messerli, Franz H., Kobrin, Isaac and Frohlich, Edward D. (1984) Enalapril improves systemic and renal hemodynamics and allows regression of left ventricular mass in essential hypertension. American Journal of Cardiology, 53 1: 105-108. doi:10.1016/0002-9149(84)90692-1


Author Dunn, Francis G.
Oigman, Wille
Ventura, Hector O.
Messerli, Franz H.
Kobrin, Isaac
Frohlich, Edward D.
Title Enalapril improves systemic and renal hemodynamics and allows regression of left ventricular mass in essential hypertension
Journal name American Journal of Cardiology   Check publisher's open access policy
ISSN 0002-9149
Publication date 1984
Sub-type Article (original research)
DOI 10.1016/0002-9149(84)90692-1
Volume 53
Issue 1
Start page 105
End page 108
Total pages 4
Place of publication Bridgewater, NJ, United States
Publisher Excerpta Medica
Language eng
Formatted abstract
Enalapril, a new angiotensin-converting enzyme inhibitor, is an effective antihypertensive agent for both renovascular and essential hypertension. It is structurally different from captopril in that it does not possess a sulfhydryl group. The systemic and renal hemodynamic, biochemical and cardiac adaptive changes induced by enalapril were studied in 8 patients with essential hypertension before and after 12 weeks of therapy. Mean arterial pressure decreased from 110 to 90 mm Hg (p <0.01), and this was mediated through a decrease in total peripheral resistance from 42 ± 3 to 32 ± 3 U (p <0.01). Cardiac index and heart rate did not change. Renal plasma flow was increased in 6 of 8 patients and renal vascular resistance decreased from 123 ± 6 to 91 ± 7 U (p <0.001). Left ventricular mass index decreased from a mean of 166 ± 29 to 117 ± 8 g/m2 (p <0.05) without impaired myocardial contractility. Thus, enalapril lowers arterial pressure by reducing total peripheral resistance without reflexive cardiac effects. It also has favorable hemodynamic effects on the kidney. This is the first report of regression of LV mass with this agent in man.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 251 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 198 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 14 Mar 2011, 10:08:20 EST