Usefulness of heart rate as an independent predictor for survival after heart transplantation

Anand, Rishi G., Reddy, Madhavi T., Yau, C. L., Myers, Leann, Amin, Rohit R., Stahls, Paul F., Dumas, Debbie, Frohlich, Edward D. and Ventura, Hector O. (2009) Usefulness of heart rate as an independent predictor for survival after heart transplantation. American Journal of Cardiology, 103 9: 1290-1294. doi:10.1016/j.amjcard.2009.01.022


Author Anand, Rishi G.
Reddy, Madhavi T.
Yau, C. L.
Myers, Leann
Amin, Rohit R.
Stahls, Paul F.
Dumas, Debbie
Frohlich, Edward D.
Ventura, Hector O.
Title Usefulness of heart rate as an independent predictor for survival after heart transplantation
Journal name American Journal of Cardiology   Check publisher's open access policy
ISSN 0002-9149
1879-1913
Publication date 2009-05-01
Sub-type Article (original research)
DOI 10.1016/j.amjcard.2009.01.022
Volume 103
Issue 9
Start page 1290
End page 1294
Total pages 5
Place of publication Bridgewater, NJ, United States
Publisher Excerpta Medica
Language eng
Abstract It was unclear whether increased heart rate (HR) increased long-term mortality after heart transplantation (HT). The aim of this study was to evaluate whether HR predicted survival after HT. A retrospective analysis of patients who underwent HT at our institution was performed. Ethnicity, gender, date of birth, age at transplantation, length of follow-up after transplantation, cardiac rhythm within 3 months after transplantation, age at death, reason for transplantation, cause of death, and baseline medications after transplantation were recorded. Continuous variables, such as HR, blood pressure, cardiac ejection fraction, presence of allograft vasculopathy, and serum creatinine, were recorded at <3 months, 6 months, and 1 year after HT, then annually to 10 years after HT. Seventy-eight patients with a mean age of 50 ± 13 years were identified. Mean survival was 8.5 ± 6.5 years. Of 78 patients, 32 patients had an HR ≤90 beats/min, and 46 patients had an HR >90 beats/min within 3 months after HT. There was a mean decrease in HR of 6 beats/min during 10 years (p <0.03). Multivariate survival analysis showed that HR >90 beats/min was a significant predictor of early mortality (hazard ratio 2.8, 95% confidence interval 1.5 to 5.1, p <0.0013). Patients with a net increase in HR during 10 years had an increased risk of death compared with patients with no change or a net decrease in HR (hazard ratio 4.7, 95% confidence interval 1.9 to 12.0, p <0.002). No significant differences in cause of death between patients with an HR ≤90 or >90 beats/min existed. In conclusion, HT patients with an HR >90 beats/min within the first 3 months after HT were 2.8 times more likely to die than patients with an HR ≤90 beats/min. Patients with a net increase in HR were 4.7 times more likely to die than those whose HR did not change or decreased over time.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:07:32 EST