Treatment of experimentally induced caval thrombosis with oral low molecular weight heparin and delivery agent in a porcine model of deep venous thrombosis

Salartash, K., Lepore, M., Baughman, R., Sternbergh, W. C., Bowen, J. C. and Money, S. R. (2000). Treatment of experimentally induced caval thrombosis with oral low molecular weight heparin and delivery agent in a porcine model of deep venous thrombosis. In: 111th Annual Meeting of the Southern-Surgical-Association, Hot Springs, VA, United States, (789-793). 5-8 December 1999. doi:10.1097/00000658-200006000-00002


Author Salartash, K.
Lepore, M.
Baughman, R.
Sternbergh, W. C.
Bowen, J. C.
Money, S. R.
Title of paper Treatment of experimentally induced caval thrombosis with oral low molecular weight heparin and delivery agent in a porcine model of deep venous thrombosis
Conference name 111th Annual Meeting of the Southern-Surgical-Association
Conference location Hot Springs, VA, United States
Conference dates 5-8 December 1999
Journal name Annals of Surgery   Check publisher's open access policy
Place of Publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Publication Year 2000
Sub-type Fully published paper
DOI 10.1097/00000658-200006000-00002
ISSN 0003-4932
Volume 231
Issue 6
Start page 789
End page 793
Total pages 4
Language eng
Formatted Abstract/Summary
Objective: This experiment evaluated enterally administered low molecular weight heparin (LMWH) combined with sodium N-[10-(2- hydroxybenzoyl)amino] decanoate (SNAD) for the treatment of induced venous thrombosis.

Summary Background Data: SNAD is a delivery agent that potentiates the gastrointestinal absorption of LMWH. Methods: Forty female pigs were equally assigned to four groups: control (saline); enteral LMWH, 2,000 IU/kg; enteral SNAD, 50 mg/kg; and enteral LMWH, 2,000 IU/kg and SNAD, 50 mg/kg. Under fluoroscopic guidance, the infrarenal vena cava was occluded with a balloon catheter. Two milliliters of ethanol was injected into the distal vena cava. The inflated balloon catheter remained in situ for 5 days, at which time animals angiographically exhibiting thrombus were randomly assigned to the four groups. Study medications were dosed at 12-hour intervals by means of a gastrostomy tube placed previously. After 7 days of treatment, thrombus was extracted. A separate group of 10 animals was used to measure plasma antifactor Xa levels for 6 hours after enteral dosing of LMWH/SNAD.

Results: The amount of residual thrombus after treatment with enteral LMWH/SNAD was significantly decreased. Antifactor Xa levels were significantly elevated in the LMWH/SNAD group versus baseline.

Conclusion: The combination of enterally administered LMWH and SNAD given for 7 days appeared to decrease caval thrombosis in this model of deep vein thrombosis. Enteral LMWH/SNAD effected an increase in plasma levels of antifactor Xa.
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 28 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 14 Mar 2011, 10:03:11 EST