Orally administered heparin for preventing deep venous thrombosis

Gonze, M. D., Manord, J. D., Leone-Bay, A., Baughman, R. A., Garrard, C. L., Sternbergh, W. C. and Money, S. R. (1998). Orally administered heparin for preventing deep venous thrombosis. In: 26th Annual Meeting of the Society-for-Clinical-Vascular-Surgery, Coronado, CA, United States, (176-178). 25-29 March 1998. doi:10.1016/S0002-9610(98)00127-5


Author Gonze, M. D.
Manord, J. D.
Leone-Bay, A.
Baughman, R. A.
Garrard, C. L.
Sternbergh, W. C.
Money, S. R.
Title of paper Orally administered heparin for preventing deep venous thrombosis
Conference name 26th Annual Meeting of the Society-for-Clinical-Vascular-Surgery
Conference location Coronado, CA, United States
Conference dates 25-29 March 1998
Journal name American Journal of Surgery   Check publisher's open access policy
Place of Publication Philadelphia, PA, United States
Publisher Elsevier
Publication Year 1998
Sub-type Fully published paper
DOI 10.1016/S0002-9610(98)00127-5
ISSN 0002-9610
Volume 176
Issue 2
Start page 176
End page 178
Total pages 2
Language eng
Formatted Abstract/Summary
Background: Sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) is an acetylated amino acid molecule that facilitates the gastrointestinal absorption of heparin. This study was undertaken to evaluate the efficacy of orally administered combination SNAC:heparin in preventing deep venous thrombosis in a standard rat model.

Methods: Forty-four adult male Sprague- Dawley rats were randomly divided into five groups: group I control, group II SNAC, group III oral heparin, group IV combination SNAC:heparin, and group V intravenous heparin. Thirty minutes after drug administration, the internal jugular vein was bathed in a sclerosant mixture for 2 minutes and reexplored at 120 minutes. Activated partial thromboplastin times (aPTT) were measured in 30 rats equally divided into three groups: group I SNAC, group II oral heparin, and group III combination SNAC:heparin. Forty-five minutes posttreatment, blood was obtained for aPTT levels.

Results: The incidence of deep venous thrombosis in the control group was 89% (8 of 9) versus 25% (2 of 8) in the combination SNAC:heparin group (p <0.01). There was also a significant reduction in clot weight among groups. Combination SNAC:heparin significantly increased aPTT levels compared with SNAC or oral heparin alone.

Conclusion: In a rat model of venous thrombosis, combination of orally administered heparin:SNAC elevated aPTT levels and significantly reduced the formation of deep venous thrombosis.
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 20:01:00 EST