Multicenter evaluation of a polyurethaneurea vascular access graft as compared with the expanded polytetrafluoroethylene vascular access graft in hemodialysis applications

Stokes, G. K., Ross, J. R., Schuman, E. D., Sternbergh, W. C., Lindberg, J. S., Money, S. M. and Lorber, M. I. (2001). Multicenter evaluation of a polyurethaneurea vascular access graft as compared with the expanded polytetrafluoroethylene vascular access graft in hemodialysis applications. In: 25th Annual Meeting of the Southern-Association-for-Vascular-Surgery, Río Grande, Puerto Rico, (465-472). 24-27 January 2001. doi:10.1067/mva.2001.117330


Author Stokes, G. K.
Ross, J. R.
Schuman, E. D.
Sternbergh, W. C.
Lindberg, J. S.
Money, S. M.
Lorber, M. I.
Title of paper Multicenter evaluation of a polyurethaneurea vascular access graft as compared with the expanded polytetrafluoroethylene vascular access graft in hemodialysis applications
Conference name 25th Annual Meeting of the Southern-Association-for-Vascular-Surgery
Conference location Río Grande, Puerto Rico
Conference dates 24-27 January 2001
Journal name Journal of Vascular Surgery   Check publisher's open access policy
Place of Publication Philadelphia, PA, United States
Publisher Mosby
Publication Year 2001
Sub-type Fully published paper
DOI 10.1067/mva.2001.117330
ISSN 0741-5214
Volume 34
Issue 3
Start page 465
End page 472
Total pages 7
Language eng
Formatted Abstract/Summary
Objectives: The purpose of this study was to compare in a randomized, prospective, and controlled study, the performance of a multilayered, self-sealing polyurethane vascular access graft (PVAG) and expanded polytetrafluoroethylene (ePTFE) vascular access grafts in hemodialysis applications. Performance measures included graft survival, complications, time to early cannulation, and hemostasis times after cannulation.

Study Design:
A total of 142 patients were randomized equally to receive one of the two grafts after meeting all eligibility requirements. All patients were followed up prospectively to 12 months or to the end of secondary patency. Specifically, this study documented the performance of the PVAG and ePTFE grafts by determining the patencies and complications for both grafts.

Results: Patient characteristics between the two groups were similar with respect to risk factors and demographic characteristics (P > .05). Life-table patencies from the date of first dialysis were primary patency: PVAG 55% versus ePTFE 47% (6 months) and PVAG 44% versus ePTFE 36% (12 months) and secondary patency: PVAG 87% versus ePTFE 90% (6 months) and PVAG 78% versus ePTFE 80% (12 months). None of these differences were significant (P > .05). Both primary and secondary patencies were also not significantly different when the date of implantation was the starting point. Adverse events and complications were similar for the two groups, except the PVAG group had a higher incidence of technical complications manifested by graft kinking when compared with the control cohort (P < .05). Additionally, there was no significant difference in complication rates between these two groups with regard to infection and bleeding. When the time to hemostasis after cannulation was compared at 5 minutes or less, there were more PVAG cannulation sites that achieved hemostasis compared with ePTFE sites, and this difference was significant (P < .0001). When time to first dialysis access was compared between the two grafts, 53.9% of all PVAG grafts were cannulated before 9 days versus none with the ePTFE grafts (P < .001). However, long-term graft survival was not significantly different when PVAG patients were stratified into early (< 9 days) and the late access (9 ≥ days) groups (P = .29).

Conclusions: The PVAG graft allows for early access without compromising long-term performance. Both PVAG and standard ePTFE grafts have similar long-term outcomes, despite early access with the PVAG vascular access grafts.
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 10:00:56 EST