Perinatal outcomes in preeclampsia that is complicated by massive proteinuria

Newman, M. G., Robichaux, A. G., Stedman, C. M., Jaekle, R. K., Fontenot, M. T., Dotson, T. and Lewis, D. F. (2003) Perinatal outcomes in preeclampsia that is complicated by massive proteinuria. American Journal of Obstetrics and Gynecology, 188 1: 264-268. doi:10.1067/mob.2003.84

Author Newman, M. G.
Robichaux, A. G.
Stedman, C. M.
Jaekle, R. K.
Fontenot, M. T.
Dotson, T.
Lewis, D. F.
Title Perinatal outcomes in preeclampsia that is complicated by massive proteinuria
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
Publication date 2003-01
Sub-type Article (original research)
DOI 10.1067/mob.2003.84
Volume 188
Issue 1
Start page 264
End page 268
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract
Objective: Current treatment of preeclampsia no longer mandates delivery for proteinuria of >5 g per 24 hours. We sought to determine whether delayed delivery of preeclampsia with massive proteinuria (>10 g/24 h) increased maternal or neonatal morbidity.

Study Design: Records of all women with preeclampsia who were delivered at <37 weeks of gestation between January 1, 1997, and June 30, 2001, were reviewed. Patients with underlying renal disease or multiple gestation were excluded. Patients were characterized as having mild (<5 g/24 h), severe (5-9.9 g/24 h), or massive (>10 g/24 h) proteinuria. Outcomes were compared using the χ2 test, one-way analysis of variance, or Fisher exact test.

Results: Two hundred nine patients met the inclusion criteria: 125 patients had mild proteinuria, 43 patients had severe proteinuria, and 41 patients had massive proteinuria. No significant differences in maternal morbidity were seen. Massive proteinuria was associated with earlier onset of preeclampsia, earlier gestational age at delivery, and higher rates of prematurity complications. After correction for prematurity, massive proteinuria has no significant effect on neonatal outcomes.

Conclusion: Women with preeclampsia and massive proteinuria did not have increased maternal morbidity compared with women with severe or mild proteinuria. Massive proteinuria appears to be a marker for early-onset disease and progression to severe preeclampsia. Neonatal morbidity appears to be a function of prematurity rather than of massive proteinuria itself.
Keyword Proteinuria
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Mon, 14 Mar 2011, 09:59:45 EST