The MisoPROM study: A multicenter randomized comparison of oral misoprostol and oxytocin for premature rupture of membranes at term

Mozurkewich, E., Horrocks, J., Daley, S., Von Oeyen, P., Halvorson, M., Johnson, M., Zaretsky, M., Tehranifar, M., Bayer-Zwirello, L., Robichaux, A., Droste, S. and Turner, G. (2003). The MisoPROM study: A multicenter randomized comparison of oral misoprostol and oxytocin for premature rupture of membranes at term. In: 23rd Annual Meeting of the Society-for-Maternal-Fetal-Medicine, San Francisco, CA, USA, (1026-1030). 3-8 February 2003. doi:10.1067/S0002-9378(03)00845-7


Author Mozurkewich, E.
Horrocks, J.
Daley, S.
Von Oeyen, P.
Halvorson, M.
Johnson, M.
Zaretsky, M.
Tehranifar, M.
Bayer-Zwirello, L.
Robichaux, A.
Droste, S.
Turner, G.
Title of paper The MisoPROM study: A multicenter randomized comparison of oral misoprostol and oxytocin for premature rupture of membranes at term
Conference name 23rd Annual Meeting of the Society-for-Maternal-Fetal-Medicine
Conference location San Francisco, CA, USA
Conference dates 3-8 February 2003
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
Place of Publication Philadelphia, PA, United States
Publisher Mosby
Publication Year 2003
Sub-type Fully published paper
DOI 10.1067/S0002-9378(03)00845-7
Open Access Status
ISSN 0002-9378
1097-6868
Volume 189
Issue 4
Start page 1026
End page 1030
Total pages 4
Language eng
Formatted Abstract/Summary
Objective: This study was undertaken to determine whether induction of labor with oral misoprostol will result in fewer cesarean deliveries than intravenous oxytocin in nulliparous women with premature rupture of membranes at term.

Study Design: Three hundred five women at 10 centers were randomly assigned to receive oral misoprostol, 100 μg every 6 hours to a maximum of two doses or intravenous oxytocin. The primary outcome measure was cesarean deliveries. Secondary outcomes were time from induction to vaginal delivery and measures of maternal and neonatal safety.

Results: The study was stopped prematurely because of recruitment difficulties. We present the results for the 305 enrolled women. There was no difference in the proportion of women who underwent cesarean delivery (20.1% in the misoprostol group, 19.9% in the oxytocin group). The time interval from induction to vaginal delivery was also similar (11.9 hours for the misoprostol group, and 11.8 hours for the oxytocin group). Maternal and neonatal safety outcomes were similar for the two treatments. More infants born to women in the misoprostol group received intravenous antibiotics in the neonatal period (16.4% vs 6.9%, P = .01), although there were no differences in chorioamnionitis or in proven neonatal infections. Women receiving misoprostol were less likely to have postpartum hemorrhage than those receiving oxytocin (1.9% vs 6.2%, P = .05).

Conclusion: Oral misoprostol does not offer any advantage in time from induction to vaginal delivery or risk of cesarean section.
Keyword Premature rupture of membranes
Misoprostol
Oxytocin
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 14 Mar 2011, 09:59:40 EST