Cyclosporine-induced hypertension: Efficacy of ω-3 fatty acids in patients after cardiac transplantation

Ventura, H. O., Milani, R. V., Lavie, C. J., Smart, F. W., Stapleton, D. D., Toups, T. S. and Price, H. L. (1993) Cyclosporine-induced hypertension: Efficacy of ω-3 fatty acids in patients after cardiac transplantation. Circulation, 88 5 Part 2: II281-II285.

Author Ventura, H. O.
Milani, R. V.
Lavie, C. J.
Smart, F. W.
Stapleton, D. D.
Toups, T. S.
Price, H. L.
Title Cyclosporine-induced hypertension: Efficacy of ω-3 fatty acids in patients after cardiac transplantation
Journal name Circulation   Check publisher's open access policy
ISSN 0009-7322
1524-4539
Publication date 1993-11
Sub-type Article (original research)
Volume 88
Issue 5 Part 2
Start page II281
End page II285
Total pages 5
Place of publication Baltimore, MD, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Background: Cyclosporine-induced hypertension may be related to vasoconstriction of the afferent arterioles in the glomeruli caused by changes in the prostaglandin profile. ω-3 Fatty acids have demonstrated vasodilatory properties related to a favorable effect in the prostaglandin profile. The purpose of this study was to evaluate the antihypertensive effects of oral supplementation with ω-3 fatty acids in cyclosporine- treated cardiac transplant recipients.

Methods and Results: The study consisted of 20 orthotopic cardiac transplant recipients with hypertension who were prospectively randomized in a double-blind fashion to receive either ω-6 fatty acids (placebo group, n=10) or ω-3 fatty acids (treatment group, n=10). Blood pressure, systemic hemodynamics, two-dimensional guided M-mode and Doppler echocardiography, and laboratory values (serum creatinine, lipid profile) were recorded at baseline and at 12 weeks. The treatment group demonstrated a significant reduction in mean arterial pressure (120±7 versus 102±7 mm Hg; P=.0001) associated with a decrease in systemic vascular resistance (2107±45 versus 1426±60 dynes · sec · cm-5; P=.0001). No changes in indexes of left ventricular structure and function occurred, except for a modest decrease in deceleration time (211±10 versus 182±12 milliseconds; P=.05), an index of left ventricular diastolic function.

Conclusions: ω-3 Fatty acids (3 g/d) reduce blood pressure by decreasing systemic vascular resistance and, therefore, can be used as an adjuvant for the treatment of hypertension in cyclosporine-treated cardiac transplant recipients. Their vasodilatory effect may be related to a beneficial change in the prostaglandin profile.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 09:55:37 EST