Complications in 100 living-liver donors

Grewal, H. P., Thistlethwaite, J. R., Loss, G. E., Fisher, J. S., Cronin, D. C., Siegel, C. T., Newell, K. A., Bruce, D. S., Woodle, E. S., Brady, L., Kelly, S., Boone, P., Oswald, K. and Millis, J. M. (1998) Complications in 100 living-liver donors. Annals of Surgery, 228 2: 214-219. doi:10.1097/00000658-199808000-00011

Author Grewal, H. P.
Thistlethwaite, J. R.
Loss, G. E.
Fisher, J. S.
Cronin, D. C.
Siegel, C. T.
Newell, K. A.
Bruce, D. S.
Woodle, E. S.
Brady, L.
Kelly, S.
Boone, P.
Oswald, K.
Millis, J. M.
Title Complications in 100 living-liver donors
Journal name Annals of Surgery   Check publisher's open access policy
ISSN 0003-4932
Publication date 1998-08
Sub-type Article (original research)
DOI 10.1097/00000658-199808000-00011
Volume 228
Issue 2
Start page 214
End page 219
Total pages 6
Language eng
Abstract Objective: A review of 100 living-liver donors was performed to evaluate the perisurgical complications of the procedure and thus to help quantify the risks to the donor. Summary Background Data: Despite the advantages of living-donor liver transplantation (LDLT), the procedure has received criticism for the risk it imposes on healthy persons. A paucity of data exists regarding the complications and relative safety of the procedure. Methods: One hundred LDLTs performed between November 1989 and November 1996 were reviewed. Donor data were obtained by chart review, anesthesia records, and the computerized hospital data base. Patient variables were compared by Fisher's exact test and the Student's t test. Results: There were 57 women and 43 men with a median age of 29. Donors were divided into two groups: group A (first 50 donors), and group B (last 50 donors). There were 91 left lateral segments and 9 left lobes. There were no deaths. Fourteen major complications occurred in 13 patients; 9 occurred in group A and 5 in group B. Biliary complications consisted of five bile duct injuries (group A = 4, group B = 1) and two cut edge bile leaks. Complications were more common in left lobe resections (55%) than in left lateral segment grafts (10%). Minor complications occurred in 20% of patients. A significant reduction in overall complications (major and minor) was observed between the groups (group A, n = 24 [45%] vs. group B, n = 10 [20%]). In addition, surgical time and hospital stay were both significantly reduced. Conclusions: Although the procedure is safe, many LDLT donors have a perisurgical complication. Surgical experience and technical modifications have resulted in a significant reduction in these complications, however. To minimize the risks for these healthy donors, LDLT should be performed at institutions with extensive experience.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 128 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 14 Mar 2011, 09:39:24 EST