Reduction in C-reactive protein through cardiac rehabilitation and exercise training

Milani, Richard V., Lavie, Carl J. and Mehra, Mandeep R. (2004). Reduction in C-reactive protein through cardiac rehabilitation and exercise training. In: 74th Annual Scientific Sessions of the American-Heart-Association, Anaheim, CA, United States, (1056-1061). 11-14 November 2001. doi:10.1016/j.jacc.2003.10.041


Author Milani, Richard V.
Lavie, Carl J.
Mehra, Mandeep R.
Title of paper Reduction in C-reactive protein through cardiac rehabilitation and exercise training
Conference name 74th Annual Scientific Sessions of the American-Heart-Association
Conference location Anaheim, CA, United States
Conference dates 11-14 November 2001
Journal name Journal of the American College of Cardiology   Check publisher's open access policy
Place of Publication San Diego, CA, United States
Publisher Elsevier
Publication Year 2004
Sub-type Fully published paper
DOI 10.1016/j.jacc.2003.10.041
ISSN 0735-1097
Volume 43
Issue 6
Start page 1056
End page 1061
Total pages 5
Language eng
Formatted Abstract/Summary
Objectives: This study was designed to assess the effects of three-month formal phase II cardiac rehabilitation and exercise training programs on high-sensitivity C-reactive protein (HSCRP) levels in patients with coronary heart disease (CHD).

Background: High-sensitivity C-reactive protein is associated with abdominal adiposity and other CHD risk factors and is a potent independent predictor of CHD events. Although weight reduction and statin therapy reduce HSCRP levels, the independent effects of cardiac rehabilitation programs on HSCRP are not well established.

Methods: We analyzed plasma levels of HSCRP in 277 patients with CHD (235 consecutive patients before and after formal phase II cardiac rehabilitation and exercise training programs and 42 "control" patients who did not attend cardiac rehabilitation). Additionally, we determined the effects of cardiac rehabilitation on HSCRP independent of statin therapy and weight loss.

Results: Rehabilitation patients improved significantly in body fat, obesity indices, exercise capacity, and other cardiac risk factors. Mean (5.9 ± 7.7 to 3.8 ± 5.8 mg/l; -36%; p < 0.0001) and median levels of HSCRP (-41%; p = 0.002) decreased significantly in the rehabilitation group but not in the control population. Similar significant reductions in HSCRP occurred in the rehabilitation patients regardless of whether they received statin therapy or lost weight.

Conclusions: Therapeutic lifestyle changes effected through a three-month cardiac rehabilitation program significantly improved numerous cardiac risk factors. Through this holistic approach to secondary prevention, we observed significant reductions in HSCRP levels. These findings identify another clinical modality of reducing HSCRP beyond use of statin drugs and suggest an additional benefit of formal phase II cardiac rehabilitation and exercise training programs.
Keyword ACS
Acute coronary syndromes
Body mass index
Coronary heart disease
High-sensitivity C-reactive protein
Oxygen consumption
Percutaneous coronary intervention
VO2
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Mon, 14 Mar 2011, 09:36:18 EST